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IL1B activates AKT. 52 / 55
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"In our previous study [XREF_BIBR], IL-1beta stimulated Akt activation in DOK and OSCC cells, thus facilitating a negative feedback regulation mechanism."
26462152
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"Addition of 1 ng/ml IL-1beta activated both p42 and p44 MAPK as well as AKT."
19155066
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"These results indicate that the p38 and MAPK and PI3K and Akt signaling pathways activated by IL-1beta play a critical role in these morphological changes, leading to VM responses."
34055597
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"We found that short-term IL-1beta and TNF-alpha treatment not only activated pro inflammatory pathways involving phosphorylation of JNK, IKKalpha, and p38MAPKalpha, but also induced strong transient a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
22513786
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"We demonstrated evidence that loss of Chop represses Hmgb1 and TLR4 signaling following UUO induction, leading to repressed NFkappaB transcriptional activity along with suppressed IL-1beta production, which then reduces TGF-beta1 production and Pi3K and Akt activity to attenuate the development of renal fibrosis."
26247732
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"XREF_BIBR, XREF_BIBR Of note, other than stimulating TGF-beta1 secretion, there is also evidence indicating that IL-1beta can activate PI3K and Akt signaling, 27 and thereby enhancing renal fibrosis."
26247732
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"The results clearly show that IL-1beta induced Akt activation in a time dependent manner; PDGF-bb or IGF-1 inhibited this process (XREF_FIG)."
22194879
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"In the current study, IL-1β did not induce significant VEGFR2 phosphorylation or Akt activation, and it induced only minimal GSK3β phosphorylation."
20548028
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"13 Thus, IL-1beta upregulation may be a key process in TLR2 mediated cardiac adaptive response to pressure overload, although the mechanisms in which the TLR2 and IL-1beta axis induces IGF-1 upregulation and Akt activation remain nonelucidated."
24249711
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"In human embryonic kidney 293 cells, IL-1beta induces IkappaB kinase beta (IKKbeta) activation, IkappaBalpha degradation, NF-kappaB transactivation, and weak Akt activation."
11976320
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"At the same time, IL-1beta is able to activate PKB via a different set of kinases such as JNK or p38MAPK, which results in induction of proliferation."
22513786
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"These results showed that IL-1beta activated the p38 and MAPK and PI3K and Akt signaling pathways, while IL-1R1 antibody significantly reduced the p38 and MAPK and PI3K and Akt signaling as compared to the IL-1beta treated group (XREF_FIG)."
34055597
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"On the other hand, IL-1beta activates PKB, which induces proliferation."
22513786
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"These results showed that the PI3K and Akt signaling pathway is activated by DEP stimulation, further up-regulating IL-8 and IL-1beta expression."
22867088
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"IL-1beta was found to stimulate MMP-9 synthesis and release by activating PI3K-Akt and MEK1-ERK signaling cascades, while p38 signaling was not involved [XREF_BIBR]."
23652767
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"Some studies indicated that IL-1beta can trigger the activation of both Akt pathway and NF-kappaB pathway, which appears to be important molecular links between inflammation and tumor [XREF_BIBR, XREF_BIBR]."
28035062
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"Trans-cinnamaldehyde inhibited the inflammation induced by IL-1β in chondrocytes through the PI3K/AKT pathway, which suggests that TCA might serve as a potential therapeutic agent for osteoarthritis treatment."
33118610
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"Therefore, we examined whether LDR modulates IL-1beta-induced Akt activity and found that LDR at both 0.5 and 1 cGy suppressed Akt activation induced by IL-1beta in chondrocytes (XREF_FIG E)."
24604706
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"For instance, it was found that metformin decreases interleukin 1 beta (IL-1beta) induced activation of proinflammatory phosphokinases Akt (protein kinase B), p38 (mitogen activated protein kinase)."
28589443
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"These western blot results showed that IL-1beta enhanced the activation of the p38 and MAPK and PI3K and Akt in breast cancer cells, and the addition of the inhibitors detained the stimulation."
34055597
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"It should be noted that the tangeretin suppresses IL-1β-induced Akt activation in human lung carcinoma cells ( xref )."
19903849
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"Furthermore, IL-1beta activated the PI3K and Akt signaling via enhancing the phosphorylation of Akt at S473 and T308."
28035062
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"Effect of IGF-1 or/and PDGF-bb on IL-1β-induced activation of Akt in chondrocytes in monolayer cultures."
22194879
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"LPS, IL-1beta, and TNF-alpha, which mediate ocular inflammation, stimulate activation of p38, ERK, and Akt kinases in the corneal cell line."
16760261
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"What’s more, AKT/P65 pathway was activated by IL-1β to promoted HIF-2α expression and B cells induced HIF-2α upregulation activated DLL4 to initiate DLL4/Notch1 signals."
32123166
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"It was further noted that reduced IL-1beta production also inhibited UUO induced PI3K and AKT signaling, and both of which ultimately protected mice from UUO induced renal fibrosis."
26247732
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"To examine the 4-MU effect on phosphorylation of NF-kappaB and AKT, early signaling events during interleukin (IL)-1beta treatment of anterior cruciate ligament (ACL)-derived cells, the peak time-point of NF-kB and PI3K and AKT phosphorylation in cells treated with IL-1 beta."
| PMC
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"The results clearly show that IL-1β induced Akt activation in a time-dependent manner; PDGF-bb or IGF-1 inhibited this process ( xref )."
22194879
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"IL-1beta also activates the PI3K and AKT axis (XREF_SUPPLEMENTARY G) and MAPKs (XREF_SUPPLEMENTARY H-S2J), in addition to several other aforementioned transcription factors."
33659877
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"Further analysis showed that IL-1beta significantly decreased activity of the PI3K and Akt pathway whereas resveratrol partly increased activity of the PI3K and Akt pathway in NP cells treated with IL-1beta."
30867252
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"Then, NLRP3 inflammasome activation can promote the release of IL-1beta from macrophages, and activated IL-1beta can activate c-Jun N-terminal kinase (JNK), IkappaB kinase (IKK), and the IRS-1 / PI3K and Akt axis via the IL-1 receptor (IL-1R)."
29497383
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"IL-1beta induces phosphorilation of Akt and activation of PI3K and AKT XREF_BIBR - XREF_BIBR and intravitreal injections of this cytokine rescued axotomized RGC from retrograde cell death XREF_BIBR."
25347773
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"According to the work done by Madrid et al. [28] , in the context of IL-1β-induced Akt activation, treatment of cells with IL-1β or expression of myr-Akt enhanced the phosphorylation and activation o[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12914935
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"35 In the previous study, it was reported that IL-1beta induces IGF-1 upregulation and Akt activation, 13 which play important roles in adaptive cardiac hypertrophy."
24249711
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"Although the observed changes were not as pronounced as those observed in the absence of Rab8a, the absence of Rab8b resulted in decreased Akt activation, decreased mRNA levels for the anti-inflammatory cytokine IL-10, and increased levels for the pro-inflammatory cytokines IL-1β and Tnfα after S. Typhimurium infection (Fig. 2c and Extended Data Fig. 3)."
33603205
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"IL-1beta, COX-2-dependent PGE 2 activated the PI3-K and AKT and p38 signaling pathways, which were in turn responsible for MMP-1 synthesis via NF-kappaB- and c-Jun-transactivating pathways."
25992485
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"A dominant negative mutant (Mal-P/H) of MyD88 adapter like protein (Mal), a protein with homology to MyD88, failed to inhibit LPS- or IL-1 beta induced Akt activity."
12874320
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"However, the effects of IL-1beta on Monocyte Chemotactic Factor-1 (MCP-1) of dental pulp cells and its relation to transforming growth factor beta activated kinase-1 (TAK1), PI3K and Akt, and MEK and ERK signaling and COX activation are not fully clear."
26492523
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"Actually, one of the key actions of IL-1beta is to activate Akt signaling; based on the canonical Wnt pathway, inactivation of the serine/threonine kinase GSK3 by Akt increases beta-catenin accumulation and expression of Tcf/Lef target genes."
24604706
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"Mechanistically, we found that formononetin inhibited IL-1β induced activation of nuclear factor kappa B and AKT by activating the phosphatase and tensin homolog."
36306560
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"LPS and IL-1beta induced phosphoylation of Akt at T308 in Traf6 +/+ MEFs in the presence of 10% FBS; this effect was reduced in Traf6 -/- MEFs (XREF_SUPPLEMENTARY)."
19713527
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"Extracellular Hmgb1 thus bound to TLR4, and by which, it activated MyD88-NFkappaB pathway to enhance IL-1beta expression, which in turn promoted TGF-beta/Smad2/3 and Pi3k and Akt signaling to exacerbate renal fibrosis."
26247732
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"The activation of Akt, PI3K, nuclear factor (NF)-kappaB, Erk, Jnk, and p38 kinase by IL-1beta and TNF-alpha was diminished with CHIR 99021 in GO cells."
32735324
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"The activation of AKT and NF-κB by IL-1β was markedly inhibited by CAPE, whereas the activity of mitogen-activated protein kinases (MAPKs) was not affected."
25314606
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"3.5 Arctigenin inhibited the PI3K and Akt signalling pathway induced by IL-1beta in human OA chondrocytes."
| PMC
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"Exogenous expression of either SHPS-1 mutants that lack SHP-2 binding function or a dominant negative mutant of SHP-2 markedly inhibited the activation of Erk 1/2 and Akt by IL-1beta, whereas wild type SHPS-1 did not."
12483539
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"We examined the activation of MAPK and Akt signal proteins by western blot and determined that IL-1beta activated all three MAPKs (ERK, p38, and JNK) and Akt."
28002421
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"IL-1beta activated the AKT pathway (XREF_FIG), ERK pathway (XREF_FIG), JNK pathway (XREF_FIG) and nuclear factor-kappaB (NF-kappaB) pathway (XREF_FIG)."
29699061
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"IL-1beta rapidly activated Akt and ERK."
24647791
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"As shown in XREF_FIG row I, IL-1beta induced activation of Akt in a time dependent manner."
21669872
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"IL-1beta activated the MAPK ( ERK , JNK , and p38 ) , AKT , and NF-kappaB signaling pathways within 48 hours of treatment ( Fig. S4A ) ."
31941995
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"As shown in xref row I , IL-1β induced activation of Akt in a time-dependent manner."
21669872