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phosphosite cbn pc11 biopax bel_lc signor biogrid tas lincs_drug hprd trrust | geneways tees isi trips rlimsp medscan sparser reach

SMAD2 increases the amount of TGFB1. 3 / 3
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"Enhanced expression of TGF-beta1 could promote SC proliferation and apoptosis, down regulation of cytokines and Smad2, 4."
"The use of LY2109761, a selective inhibitor of TGF-beta1 and Smad2, diphenyliodonium (DPI), and/or astragaloside IV (AST IV is a monomer located in an extract of astragaloside) decreased the NOX4 expression, the level of ROS, and the TGF-beta1 and Smad2 expression, suggesting that inhibitions of the NOX4 and TGF-beta1 and Smad2 pathways downregulate apoptosis in HUVECs 30."
"TGF-beta 1 -induced TTC3 expression was inhibited by the knockdown of SMAD2 and SMAD3."