IndraLab

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SMAD2 increases the amount of TGFB1. 9 / 9
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"Then, we found that depletion of GPR37 resulted in a decrease in the expression of TGF-beta1 as well as the extents of Smad2 and Smad3 phosphorylation, while overexpression of GPR37 presented opposite outcomes."
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"Furthermore, siRNA mediated knockdowns of Smad2 and Smad3 significantly down-regulated the expression of both TGFB1 and SMAD7, whereas CTGF induction was weakly affected by the knockdowns, but not as much as siPYK2 treatment."
| PMC
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"Smad2 and 3 are, subsequently, phosphorylated by the activated TbetaRI, leading to their association with Smad4 and translocation to the nucleus where the Smad2, 3, 4 complex initiates gene transcript[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The use of LY2109761, a selective inhibitor of TGF-beta1 and Smad2, diphenyliodonium (DPI), and/or astragaloside IV (AST IV is a monomer located in an extract of astragaloside) decreased the NOX4 expression, the level of ROS, and the TGF-beta1 and Smad2 expression, suggesting that inhibitions of the NOX4 and TGF-beta1 and Smad2 pathways downregulate apoptosis in HUVECs 30."
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"Attenuates expressions of TGFb1, Smad2, phosphorylated Smad2, Smad3, and CTGF andinduces expression of the Smad7 Suppresses the activation of HSCs and reduces collagen accumulation and the expression of type I collagen protein."
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"TGF-beta 1 -induced TTC3 expression was inhibited by the knockdown of SMAD2 and SMAD3."
30696809
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"p40F, p40N180 and p40N120 significantly stimulated Tgfb1 gene expression in YAMC cells (Figure 3c) that corresponded to an increase in TGFβ protein in YAMC culture supernatants (Figure 3d) and activated SMAD2, a TGFβ-regulated target (Figure 3e)."
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"Enhanced expression of TGF-beta1 could promote SC proliferation and apoptosis, down regulation of cytokines and Smad2, 4."
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"The gene expression analysis of fibrotic genes in LFC showed that knockdown of p-Smad2 by siRNA significantly reduced the protein expression level of TGF-beta1 compared to other groups."
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