IndraLab

Statements

Ethanol increases the amount of KCNMA1. 8 / 9
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"33 Thus, alcohol induced upregulation of miR-9 shifts BK channel expression toward more tolerant isoforms."
21606928
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"Expression of the fly BK channel is upregulated by ethanol exposure and its function is required for the development of rapid ethanol tolerance; induction of BK channel expression is in fact sufficient to induce ethanol resistance, mimicking the tolerant state."
22350798
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"In Drosophila, expression of slo is induced by organic solvent sedation (benzyl alcohol and ethanol) and this increase in neural slo expression contributes to the production of functional behavioral tolerance (inducible resistance) to these drugs."
25967280
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"Alcohol has been shown to modulate BK channel expression, which may lead to tolerance [XREF_BIBR, XREF_BIBR]."
19756388
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"Thus, miR-9-induced destabilization of alcohol sensitive BK channels likely contributes to alcohol tolerance and addiction by promoting the expression of more tolerant BK channel isoforms."
22737160
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"We found that up-regulation of BK channel gene expression by alcohol can by itself generate a substantial degree of tolerance."
28442993
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"A recent study in primary cultures of rat hippocampal neurons shows a complex pattern in BK channel membrane expression in response to 25 mM ethanol applied for 10 min, 3, 6, and 24 hours : total internal fluorescence (TIRF) microscopy shows that perimembrane channel expression increases during 10 min and 3 hours applications, decreases after 6 hours, and returns to pre-ethanol levels after a day of ethanol exposure."
27238266
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"EtOH exposure increases Slo expression in specific neurons, suggesting a role in adaptation to substance exposure."
40236633