IndraLab

Statements

USP14 leads to the ubiquitination of AR. 5 / 5
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"However, multi‐center‐based investigation is needed for further validation of its predictive value.It has been shown that silencing of USP14 could block the cell cycle progression and elicit caspase‐dependent apoptosis in MM cells.13 Also, inhibition of USP14 led to G0/G1 arrest by accelerating the ubiquitination and degradation of AR in prostate cancer cells."
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"USP14 inhibits the ubiquitination and degradation of AR."
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"Consistently, genetic and pharmacological inhibition of USP14 was shown to promote the ubiquitination and degradation of AR and retard the growth of PC cells by arresting them in the G0/G1 phase (Table 2) (Liao et al., 2017)."
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"USP14 has been reported to compete with MDM2 to bind to AR and prevent the ubiquitination and degradation of AR [37]."
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"We found that (i) USP14 could bind to AR, and additionally, both genetic and pharmacological inhibition of USP14 accelerated the ubiquitination and degradation of AR; (ii) downregulation or inhibition of USP14 suppressed cell proliferation and colony formation of LNcap cells and, conversely, overexpression of USP14 promoted the proliferation; and (iii) reduction or inhibition of USP14 induced G0/G1 phase arrest in LNcap prostate cancer cells."
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