IndraLab

Statements

Ezogabine activates KCNQ3. 10 / 10
1 1 | 7 1
reach
"Recently, Wickenden et al. (2001) have also shown that retigabine can activate the KCNQ5 and KCNQ3 heteromer expressed in CHO cells."
11890900
reach
"Moreover, KCNQ3 and KCNQ5 channels are potently activated by the anticonvulsant retigabine (Wickenden et al., 2001)."
12890507
sparser
"Retigabine activates mainly heteromeric Kv7.2 and Kv7.3 channels and as a result causes changes in resting membrane potential towards more negative levels (ie hyperpolarization)."
29101377
reach
"The antiepileptic drug retigabine rescued KCNQ3 currents that were abolished by a mutation disrupting E-M coupling, suggesting that modulating the E-M coupling in KCNQ channels presents a potential strategy for antiepileptic therapy."
35857840
dgi
No evidence text available
reach
"Retigabine potentiation of KCNQ3 * channels was retained with F 3 -Trp substitution at Trp265 (XREF_FIG), a substitution that still potently diminishes the negative electrostatic potential on the face of the side chain (XREF_FIG), indicating that a cation-pi interaction of Trp265 with retigabine or some other entity (perhaps another channel residue) is not required for retigabine effects."
26333338
reach
"Retigabine has been the most characterized activator of KCNQ channels and has been shown to potentiate KCNQ2, KCNQ3, KCNQ4, and KCNQ5, without activating KCNQ1, thereby avoiding potential cardiac effects [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
33801540
reach
"The M-type current was activated by 1) 10 muM retigabine, an opener of all KCNQ channels except KCNQ1, 2) 10 muM zinc pyrithione, which augments all KCNQ channels except KCNQ3, and 3) 50 muM N-ethylmaleimide, which activates KCNQ2, KCNQ4, and KCNQ5, but not KCNQ1 or KCNQ3, channels."
22135213
reach
"Remarkably, however, this single atom alteration in each of the KCNQ3 * subunits entirely abolishes retigabine activation of KCNQ3 * channels (XREF_FIG)."
26333338
signor
No evidence text available
Other