IndraLab

Statements

MDM2 decreases the amount of CDKN1A. 22 / 32
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"In both doxorubicin-untreated and -treated cells, overexpression of Mdm2 FL or MdmX FL led to decreased p21 protein levels."
32075226
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"When P-a were treated with Lipo246 EVs and SAR405838 for 96h, the EV inhibitory effect on p53 and p21 was abrogated (lane four) compared to P-a treated with Lipo246 EVs (in lane three), suggesting that uptake of MDM2 DNA by P-a inhibited p53 and p21 expression."
31387924
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"MDM2 knockdown increased p53 and p21 expression, irrespective of p53 mutational status, in p53 wild-type LPS141 and MESO924."
25888633
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"As shown in Figure XREF_FIG, MDM2 suppression increased levels of p53 and p21 in all wt TP53 cells."
25621298
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"As expected, inhibition of MDM2 with RG7388 induced p21 WAF1 and CIP1 expression by reactivating p53 in LNCaP cells due to strong inhibition of MDM2 [XREF_BIBR]."
30700046
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"MDM2 shRNA1 knockdown increased p53 and p21 expression in wild-type p53 cell lines, induced p27 expression in MESO428 and JMN1B, and decreased cyclin D1 expression in MESO428 and MCF7, but had no effect on cyclin D1 expression in MESO924, MESO296, and JMN1B."
27129163
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"PD166866 and RG7112, an MDM2 and p53 inhibitor, cooperatively inhibited the colony formation and distal seeding of LSCC cells (P < 0.01), and upregulated the expression of p53 and p21."
33710818
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"Although comparable in level to that achieved by treatment with the p53 activators actinomycin D and nutlin-3, the increases in p53 and p21 after downregulation of Mdm2 were not sufficient to trigger cell cycle arrest."
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"Consequently, in HPAC cells, the levels of wild type p53 and p21 Waf1 and CIP1, both of which are negatively regulated by MDM2, 7 were elevated."
25016295
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"The inhibition of MDM2 with anti-MDM2 antisense oligonucleotide or Short Interference RNA targeting MDM2 significantly elevated p21 protein levels in PC3 cells (p53 null)."
14761977
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"Silencing Mdm2 or Akt1 upregulated p21 expression, whereas Akt1 overexpression downregulated p21 at the promoter and protein levels in p53WT cells."
29515768
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"As a confirmation of the effect of Nutlin3A, the data showed that exogenous HDM2 mediated decrease in P53 and P21 expression was partially blocked by Nutlin3A (XREF_FIG)."
24240108
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"Overexpression of hdm2 resulted in a decrease in the level of p21waf1"
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"In cells lacking p53, Mdm2 overexpression results in decreased p21 protein levels, whereas Mdm2 knockdown increases p21 protein levels and decreases proliferation [32,33]."
19447627
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"As Mdm2 has been shown to reduce p21 protein levels under some conditions (45, 46), this may reflect impaired Mdm2 induction by the mutant (Figs."
34045312
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"Furthermore, specific inhibition of AKT with triciribine or knockdown of MDM2 with small interfering RNA largely restored p21 expression in PSMC5-knockdown H460 cells."
26592665
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"We verified that knockdown of Mdm2 upregulated the p53 and p21 protein levels."
29515768
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"Mdm2 has been shown to negatively regulate p21 protein levels in a p53 independent manner, which can account for this increase in the p53-null H1299 line."
28806397
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"Next, we tested whether the inhibitors of Wip1 and Mdm2 are increasing p21 and Mdm2 levels in a p53 dependent fashion."
27183917
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"PD166866 and RG7112, an MDM2/p53 inhibitor, cooperatively inhibited the colony formation and distal seeding of LSCC cells (P < 0.01), and upregulated the expression of p53 and p21."
33710818
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"It is known that the expression of p21 is negatively regulated by MDM2 and AKT 36."
29133857
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"Similarly, MDM2 inhibition with MI-219 was shown to elevate p21 levels and produce p53 dependent sensitization of LNCaP prostate cancer cells to radiation, antiandrogen therapy, and the combination of the two."
30700046