IndraLab

Statements

TNFAIP3 inhibits MALT1. 2 / 2
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"Activation of NFkappabeta through the canonical pathway related to TCR activation requires MALT1 signaling, which is suppressed by TNFAIP3 through deubiquitination 37."
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"The fact that MALT-1 ubiquitination by TRAF6 is essential for TCR- and BCR-induced activation of NF-κB and evidence that MALT-1 plays an important role in the pathogenesis of several autoimmune diseases (e.g., Multiple Sclerosis; Brüstle et al., xref ; Mc Guire et al., xref ) and lymphomas (e.g., Marginal B zone lymphoma and ABC-DLBCL; Ngo et al., xref ; Vega et al., xref ) suggest that MALT-1 inhibition by A20 plays an important role in the prevention of autoimmunity and lymphomas (Figure xref )."
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