IndraLab

Statements

3-(trimethylsilyl)propane-1-sulfonic acid inhibits STAT1. 4 / 4
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"DSS induced colitis was attenuated in male STAT1 incrementIEC mice."
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"Our findings suggest that SOCS-1, particularly in T cells, prevents the development of DSS induced colitis in mice by inhibiting IFN-gamma and STAT1 signaling and by subsequently regulating Treg cell development."
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"However, AOM and DSS induced STAT1 activation was dramatically reduced in colons of Casp1 -/- mice during early stages of tumorigenesis (day 15 post-AOM) (XREF_FIG)."
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"DSS induced colitis was reduced in STAT1 knockout mice (Bandyopadhyay etal., 2008; Berry etal., 2012) whereas mice with haploinsufficiency of SOCS1, a negative regulator of STAT1, showed more severe colitis (Horino etal., 2008)."
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