IndraLab

"141516 The recently reported K channel is widely expressed in the central nervous system and regulates central neuronal excitability.3 TRESK currents are increased up to 3-fold by clinical concentrations of isoflurane, halothane, sevoflurane, and desflurane.17 TRESK also plays an important role in nociceptor excitability18 and in the pain pathway, therefore, TRESK is likely to be a major target of many volatile anesthetics and neuroprotective agents.Kang and Kim19 reported that the background K current of K channels in the DRG regulates DRG cell excitability; channel inhibition causes increased excitability."

"Human TRESK is potently activated by halothane, isoflurane, sevoflurane, and desflurane, making it the most sensitive volatile anesthetic activated K2P channel yet described."

"In the Xenopus oocyte and COS-7 cell expression systems, clinical doses of isoflurane, halothane, sevoflurane, and desflurane strongly increase TRESK currents up to three-fold by increasing the open probability [XREF_BIBR]."