IndraLab

Statements

24,25-Dihydroxyvitamin D inhibits CTSL. 6 / 6
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"In addition, our in vitro data show that vitamin D inhibits CTSL mediated degradation of 53BP1."
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"In support of this notion, vitamin D treatment inhibits CTSL mediated degradation of 53BP1 in a variety of contexts, including BRCA1 deficient and lamin A/C deficient cells XREF_BIBR, XREF_BIBR."
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"Vitamin D depletes or inhibits CTSL leading to increased genomic instability and compromised cancer cell proliferation after irradiation and treatment with PARP inhibitors XREF_BIBR."
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"Vitamin D treatment inhibits CTSL mediated degradation of 53BP1 and stabilizes VDR and BRCA1 levels."
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"In addition, vitamin D stabilizes, at least partially, the levels of 53BP1 protein in senescent cells (XREF_FIG), without affecting 53BP1 transcripts levels (XREF_FIG), which could be explained by the role that vitamin D plays inhibiting CTSL activity 25."
27041576
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"We previously demonstrated that vitamin D inhibits CTSL activity and stabilizes 53BP1 protein in mouse embryonic fibroblasts."
23337117