IndraLab

Statements

ATXN3 activates Interferon. 3 / 3
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"Our study identified both STUB1 and ATXN3 also function as negative regulators of both RIG-I signaling and IFN signaling further supporting a critical functional coupling of RIG-I and IFN signaling and the UPR."
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"ATXN3 enhances type 1 IFN signaling during viral infection through deubiquitinating and stabilizing HDAC3 [90]."
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"Unlike USP2A, the deubiquitinating enzymes BRCC36, USP13, and USP39 positively regulate IFN activities by attenuating the polyubiquitination level of STAT1, and this process is independent of IFN treatment, which suggests divergent functional roles of these DUBs under differential contexts.Additionally, ATXN3 does not affect IFN-I production during viral infection but positively regulates IFNAR1-mediated downstream signaling by targeting HDAC3 (108)."
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