IndraLab

Statements


Modified CDK4 leads to the phosphorylation of RB1. 9 / 9
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"At the cellular level, the TL mediated decrease in CDK4 protein levels in HeLa cells causes reduced phosphorylation of Rb resulting in cell cycle arrest at the G1 phase."

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"CDK2 and CDK4 overexpression in oral SCC may elevate pRB phosphorylation and permit more rapid entry of cancer cells into S-phase."

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"PGA 2 was shown to elevate p21 expression and inhibit the activation of cdk2 and cdk4 due to dramatic decrease in the levels of cyclinD1 and cdk4, blocking the hyperphosphorylation of retinoblastoma p[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"

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"Higher levels of CDK4 may lead to RB phosphorylation impairing its function in cell cycle control [XREF_BIBR]."

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"Frankincense essential oil suppressed cyclin D1 and cdk4 expression may lead to suppressed Rb phosphorylation which results in suppressed cell cycle progression in pancreatic cancer cells [XREF_BIBR]."

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"Over-expression of cyclin-D or CDK4 kinases from amplification, mutation, or chromosomal translocation can lead to enhanced Rb phosphorylation and poor prognosis."

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"RAS and CDK4 co-expression promotes Rb phosphorylation, ultimately resulting in human invasive neoplasm."

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"Furthermore, ectopic expression of cyclin D1 but not CDK4, substantially increased RB phosphorylation and conferred substantial resistance to CDK4/6 inhibitors in SCCOHT-1 and BIN-67 cells."

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"Specifically, increased expression of CDK4 due to elevations in copy number and through the activation of the mTOR pathway via PTEN and TSC2 mutations leads to phosphorylation of Rb in a majority of human PanNETs."