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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

OTUD3 inhibits Neoplasm Metastasis. 2 / 3

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"OTUD3 accelerates lung cancer cell growth and metastasis via regulating GRP78 To evaluate whether OTUD3 promotes tumor progression through regulating GRP78 , we depleted endogenous GRP78 in OTUD3-overexpressing H1299 and A549 cells and observed that the inhibition of endogenous GRP78 expression attenuated OTUD3-induced cell growth and migration ( Fig. 7a-f ) ."

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"Secondly , although OTUD3 can inhibit tumor growth and metastasis by stabilizing PTEN in breast cancer , hepatocellular cancer , colon cancer , and cervical cancer , loss of OTUD3 suppressed the tumorigenesis of lung cancer in vitro and in vivo ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...