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Okadaic acid inhibits NFKBIA. 7 / 7
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"In human neutrophils and HL-60 cells, OA and orthovanadate, an inhibitor of tyrosine phosphatase, stimulated the activation of NF-kappaB and rapid degradation of IkappaBalpha."
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"The amounts of IkappaBalpha decreased in MG63 cells treated with OA for 2 h in a dose dependent fashion up to 100 nM (data not shown)."
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"As shown in Fig. 3C, OA drastically inhibited the serine/threonine phosphatase activity, correlating with the induction of NFkappaB DNA binding and nuclear IkappaBalpha degradation.Next, we sought to [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12921778
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"Therefore, we evaluated the effect of Wogonin on the degradation of IkappaBalpha and found that stimulation of OA chondrocytes with IL-1beta alone caused degradation of IkappaBalpha within 15 minutes of treatment, and was not blocked by treatment with Wogonin indicating that Wogonin mediated suppression of IL-6, COX-2, iNOS and MMPs was not due to the inhibition of the activation of NF-kappaB in IL-1beta-stimulated OA chondrocytes."
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"Stimulation of OA chondrocytes with AGE-BSA induced the degradation of cytoplasmic IkappaBalpha and increased the nuclear level of NF-kappaB subunits p65 and Rel-B (XREF_FIG)."
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"However, the NFkappaB activation and IkappaBalpha degradation induced by OA are temporally delayed compared to those in LPS or TNF stimulated neutrophils (Figs. 1 and 2), or compared to the NFkappaB a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12921778
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"Therefore, we evaluated the effect of Wogonin on the degradation of IkappaBalpha and found that stimulation of OA chondrocytes with IL-1beta alone caused degradation of IkappaBalpha within 15 min of t[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
28237856