IndraLab

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"Because the maintenance of caveolae depends on not only caveolin-1 and associated proteins but also on free CLR levels in the membrane ( xref ; xref ), the modification of BK current by CLR-depleting treatment can be explained by the loss of direct BK channel inhibition by CLR (Sections 4.3.1 and 4.3.2 ), and/or by alteration of local raft organization with disruption of interactions between BK and raft components, caveolin-1 in particular."