IndraLab

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DEX activates KCNMA1. 4 / 4
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"Therefore, we proposed that DEX might increase BK channel currents, which contribute to the lower [K +] i and the activation of NLRP1 inflammasome in hippocampal neurons."
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"Chronic DEX exposure can induce neurodegeneration and accelerate NLRP1 inflammasome activation by modulating BK channel in hippocampal neurons."
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"Recently, the acute application of DEX has been shown to increase BK channel activity in pituitary GH3 and AtT-20 cells and reduce the firing of action potentials in GH3 cells [XREF_BIBR]."
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"Acute DEX exposure may activate BK channel and induce low [K +] i via non gene effects, and chronic DEX exposure may upregulate expression of BK channel protein via gene effects, which may accelerate NLRP1 inflammasome activation and induces neurodegeneration in hippocampal neurons."
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