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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

COPS5 bound to MIF activates NFkappaB. 1 / 1

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"Consistent with its diverse functions and the large array of cell types that produce it, the downstream effects of MIF are extensive : MIF activates MAPK signaling pathways 16, promotes LPS stimulation through TLR4 17, interacts with Jab1 to increase transcription of AP-1 target genes 18, and activates NF-kappaB 19."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...