Other Services

This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Unacetylated TP53 decreases the amount of TP53. 2 / 2

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"Parallel to the increased NAD+ levels, SIRT1 is further stimulated directly by activated AMPK which deacetylates the tumor suppressor p53, inhibiting transactivation and p53 mediated gene expression."

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"82, 83) or by recruiting HDAC1 to deacetylate p53, thus allowing MDM2 to ubiquitinate p53 and reduce p53 levels (84)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...