IndraLab

Statements

JAK2-V617F phosphorylates STAT3. 5 / 5
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"JAK2 V617F induces constitutive phosphorylation of STAT3 and STAT5, and uses signalling targets such as Ras/MEK/ERK and PI3K and Akt pathways."
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"In addition, the Jak2 V617F mutation contributes to myelofibrosis by constitutively phosphorylating STAT3 and diminishing myeloid cell apoptosis."
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"In ET patients, both JAK2 V617F and CALR Mut bind to TPOR; JAK2 V617F enhances the phosphorylation of STAT1 and STAT3 but CALR Mut promotes STAT3 and STAT5 activation."
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"The JAK2 V617F mutation leads to constitutive STAT3 phosphorylation and potentially leads to inhibition of Stathmin 1 activity via STAT3."
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"The constitutively active JAK2 mutant V617F is found in many patients with myeloproliferative diseases (Levine and Gilliland, 2007), and constitutively phosphorylated STAT3 is found in many solid tumours and haematopoietic malignancies (Lim and Cao, 2006)."
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