IndraLab

Statements

USP11 binds CDKN1A. 5 / 5
1 | 1 3
sparser
"In the nucleus, USP11 binds to p21, catalyzes the removal of polyubiquitin chains conjugated onto p21, and stabilizes p21 protein."
29666278
biogrid
No evidence text available
23443559
reach
"In the nucleus, USP11 binds to p21, catalyzes the removal of polyubiquitin chains conjugated onto p21, and stabilizes p21 protein."
29666278
sparser
"Our findings provide the first evidence that ubiquitinated p21 in the cytoplasm can be recycled through USP11-mediated deubiquitination, and we identified the USP11-p21 axis in the cytoplasm as a potential therapeutic target for breast cancer control."
35414784
sparser
"Knockdown of USP11 results in the activation of DNA damage-response pathways, leading to hypersensitivity of cells to genotoxic stress ( xref ); (iii) in primary human fibroblasts knockdown of USP11 results in characteristics of senescence, including proliferative arrest and enlarged nucleoli ( xref ); and (iv) USP11 interacts with p21 to regulate cell cycle progression and DNA damage responses ( xref )."
30373771