IndraLab

Statements

CYLD inhibits activation. 26 / 26
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"CYLD inhibits TRAIL-mediated NF-kappaB activation and enhances the sensitivity of HCC cells to TRAIL-triggered apoptosis."
16627981
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"It has also been reported that optineurin is required for CYLD-dependent inhibition of NF-κB activation in immune cells ( xref )."
26527009
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"As CYLD could not inhibit NF-κB activation in H486R expressing cells, we next examined whether CYLD can deubiquitinate RIP in presence of H486R mutant."
21408173
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"Consequently, CYLD inhibits the activation of the transcription factor NF-κB, which plays an important role for immune responses."
23825949
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"Recently, it has been reported that CYLD inhibits the activation of NF-κB by IL-1β in 293T cells ( xref )."
14676304
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"Lastly, we show that the K63 deubiquitinylating enzyme CYLD can reverse RIP2-mediated NEMO ubiquitinylation and that CYLD can strongly inhibit RIP2-induced NF-kB activation."
15620648
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"Consistent with the requirement of ubiquitination in RIG-I function, CYLD potently inhibits RIG-I-mediated activation of the IFN-beta promoter."
18467330
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"CYLD inhibits Tax-stimulated IKK activation via deubiquitinating Tax, although the CYLD-mediated Tax deubiquitination does not affect Tax activation of Tak1."
21824392
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"Here we provide clear evidence that CYLD inhibits NTHi-induced activation of ERK ( xref ), and we also demonstrate that CYLD controls IL-8 expression via specifically targeting ERK phosphorylation by activating the ERK pathway with a constitutively active form of MEK ( xref )."
25389768
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"The familial CYLD (cylindromatosis tumor-suppressor gene), which is a DUB, inhibits the activation of nuclear factor κB in a manner that depends on the deubiquitinating activity of CYLD."
18499164
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"We thus asked whether CYLD inhibited ERK activation."
25389768
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"In addition, NF-κB activation by CC2D1A requires the ubiquitin E2 Ubc13 and is inhibited by CYLD."
20529849
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"Expression of a non-cleavable form of CYLD inhibited activation of the JNK pathway and expression of AP-1 target genes in a T-cell line, although CYLD silencing only minimally increased JNK activation [ xref ], possibly because of redundancy with other deubiquitinating enzymes."
26507244
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"In doing so, CYLD inhibits IKK activation by agents such as TNFα, IL-1β and phorbol ester (PMA)."
15196553
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"Upon knockdown of optineurin, CYLD was unable to inhibit TNFα-induced NF-κB activation and showed drastically reduced interaction with ubiquitinated RIP."
21408173
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"Furthermore, CYLD inhibits NF-κB activation by TNF and TLR/IL-1 family members ( xref – xref )."
14676304
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"CYLD inhibits NTHi-induced activation of ERK."
25389768
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"However, the reduced binding to ubiquitin may also contribute towards its effect on CYLD-dependent inhibition of NF-κB activation."
21408173
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"A20 and CYLD cooperatively inhibit gene activation but oppose each other to regulate TNF-induced cell death via their respective activities on linear ubiquitin."
26670046
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"Our results indicate that EAC inhibits the activation of NF-kappaB, and may provide a molecular basis for drug development using EAC as an anti-invasive agent in the prevention and treatment of cancer."
17316946
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"Collectively, it is evident that CYLD specifically inhibits the activation of ERK induced by bacterial pathogen in both human and mouse cells."
25389768
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"In the search for the tumor suppressor function of CYLD, several laboratories reported that CYLD can inhibit the activation of the classical NF-κB p65/p50 transcription factor ()."
16713561
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"CYLD inhibits Tax-stimulated activation of IKK but not that of Tak1."
21824392
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"In the presence of WT Cyld NF-κB transcriptionally induces CYLD, which in turn inhibits NF-κB activation ( xref , xref , xref ), thereby forming a self-regulated signaling loop."
27478875
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"In summary, we have identified TRIP as interactor of CYLD and show that CYLD inhibits NF-κB activation by TNF-α."
14676304
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"Moreover, EAc inhibited the activation of Nod like receptor protein-3 (NLRP3) inflammasome complex, caspase-8 and activated NF-E2-related factor 2 (p-Nrf2)."
31628913