IndraLab

Statements

USP11 activates Ubiquitin. 11 / 11
| 11
reach
"USP7 cut the polyubiquitin chain into varying lengths, whereas USP11 primarily produces monoubiquitin by cleaving ubiquitin from the free end of the polyubiquitin chain."
39145935
reach
"ATAD5 (1 to 603) enhanced USP7- and USP11-mediated Ub–PCNA deubiquitination on DNA, despite the relative weak interaction between ATAD5 and USP7–USP11."
39145935
reach
"Moreover, Heeyoung Yang et al. [30] found that USP11 regulates liver disease status by removing the K63 ubiquitin chain of KLF4; and Dan Wang et al. [31] identified that USP11 drives Peg10 gene expression and activates lung epithelial cells by removing the K63 ubiquitin chain of phosphorylated E2F1."
35715413
reach
"Since USP11 levels in AGS cells were restored by MG132 treatment, the difference in USP7 effects in the two cell lines might reflect different turnover rates of USP11 in the two cell backgrounds, such as could be caused by different levels of USP11 targeted ubiquitin ligases."
30367141
reach
"USP11 upregulates IkappaB kinase alpha in a ubiquitin independent manner XREF_BIBR, while USP18 has been shown to negatively regulate interferon signalling through protein interactions that are independent of its isopeptidase activity XREF_BIBR."
21305000
reach
"Senescent cells also directly secrete TGF-β1 to remodel the microenvironment [175] , and the deubiquitinating enzyme Usp11 within it inhibits ubiquitin degradation of TβR-Ⅱ, which promotes the activat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
38484858
reach
"However, it is currently unknown whether there is a functional interaction between UAF1–USP1, USP7, USP11, and ATAD5 that leads to Ub–PCNA deubiquitination.We have previously reported that ATAD5–RLC can unload mono-Ub or poly-Ub–PCNA from DNA (46)."
39145935
reach
"These results demonstrated that the increased expression of USP11 in renal tubular cells prevents the ubiquitin degradation of KLF4 and that elevated KLF4 promotes inflammation and renal fibrosis by initiating tubular cell pyroptosis."
39147900
reach
"For example, Xiaolin Zhu et al. [28] identified that USP11 promotes ovarian cancer chemoresistance by removing the K48 ubiquitin chain of BIP."
35715413
reach
"Mazin A Al-Salihi et al. [29] found that USP11 augmented TGFβ signaling by removing the K48 ubiquitin chain of ALK5."
35715413
reach
"Recent study has shown that USP11 promoted cardiomyocyte pyroptosis and exacerbated myocardial ischaemia-reperfusion injury by binding to TRAF3 protein and hydrolysing its ubiquitin chains (Ref."
38525836