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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

USP11 activates Ubiquitin. 2 / 2

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"Since USP11 levels in AGS cells were restored by MG132 treatment, the difference in USP7 effects in the two cell lines might reflect different turnover rates of USP11 in the two cell backgrounds, such as could be caused by different levels of USP11 targeted ubiquitin ligases."

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"USP11 upregulates IkappaB kinase alpha in a ubiquitin independent manner XREF_BIBR, while USP18 has been shown to negatively regulate interferon signalling through protein interactions that are independent of its isopeptidase activity XREF_BIBR."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...