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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Slo gene activates KCNMA1. 1 / 1

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"Notably, the isogenic mutant of slo (3348Deltaslo) was strongly impaired in its ability to induce CysLTs production, and the knock-in of a double mutated version of the slo gene (3348slodm), lacking toxicity and with severely reduced cell binding capacity XREF_BIBR, failed to restore SLO activity, suggesting the involvement of the two mutated sites in the SLO binding to human TMC and to the TLR4 receptor (XREF_FIG panel f)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...