IndraLab

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"Such noncoding pre-miR variants may modulate the posttranscriptional regulation of gene expression and thereby be associated with diseases; for example, single nucleotide polymorphisms in pre-miR-27a, pre-miR-196a2, pre-miR-423, and pre-miR-618 were strongly associated with breast cancer risk. xref In neuropsychiatric disease research, the miR-137 gene locus was associated with increased schizophrenia risk with genome-wide significance; moreover, miR-137 targets the genes CSMD1 , C10orf26 , CACNA1C , and TCF4 which are among schizophrenia-associated risk genes. xref Expressing noncoding variants of miR-137 schizophrenia-associated single nucleotide polymorphism alleles in human neurons led to increased miR-137 expression and gain-of-function, resulting in impaired vesicle release in vitro, along with deficits in hippocampus-dependent learning and memory in mice. xref The same study demonstrated that sequestering endogenous miR-137 by a “sponge” construct (compared with an empty vector backbone as control) corrected the anomalous synaptic phenotypes induced by these miR-137 variants."