IndraLab

Statements

ATXN3 activates PRKN. 9 / 9
| 9
reach
"Supporting the notion that polyglutamine expansions alter ataxin-3 function, it was recently reported that pathogenic ataxin-3 targets the E3 ligase parkin for autophagic degradation, unlike wild-type ataxin-3, which rescues it through deubiquitination [XREF_BIBR]."
21704388
reach
"Only the expanded version of Ataxin-3 was shown to promote the clearance of Parkin through autophagy, which was verified in vivo [61]."
36831318
reach
"The MJD-associated polyQ tract expansion was observed to enhance the deubiquitinating ability of Ataxin-3 and further mitigate Parkin function."
36831318
reach
"These findings were further confirmed and extended in cells, with the presence of the expanded form of ataxin-3 promoting clearance of parkin through the autophagy pathway."
23653622
reach
"Hence, it is likely that ataxin-3 edits ubiquitin chains to target Parkin to different cellular pathways such as DNA repair and autophagy (see Section 3)."
22666630
reach
"Remarkably, mutant but not wild-type ataxin-3 promotes the clearance of parkin via the autophagy pathway."
20940148
reach
"In MJD, these partnership are not only disrupted, but the presence of the expanded ataxin-3 now promotes clearance of both parkin and CHIP, which over time can have deleterious consequences on neurons in MJD and PD."
23653622
reach
"As mutant, but not wild-type ataxin-3 promotes clearance of parkin via the autophagy pathway, there seems to be a possibility that increased turnover of parkin contributes to pathogenesis in MJD."
24348458
reach
"Moreover, mutant but not wild-type ataxin-3 promotes the clearance of parkin via the autophagy pathway, raising the intriguing possibility that increased turnover of parkin may contribute to the pathogenesis of MJD and help explain some of the Parkinsonian features in MJD."
23653622