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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

MDM2 inhibits TP53-R158G. 1 / 1

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"H2170 LUSC cells that are homozygous for p53 R158G demonstrated impaired MDM2 and CDKN1A transactivation when treated with Nutlin-3a, a MDM2 antagonist, as compared to MRC5 (p53 wt) cells, indicating loss of p53 function."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...