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USP7 activates cell growth. 29 / 29
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"Depletion of USP7 in RNF4 knockouts reduces cell growth and increases genome instability."
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"USP7 inhibition severely impaired the cell growth of MOLM-13, OCI-AML3, K562, and HL60 AML cell lines (Figure 8A)."
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"In particular, pharmaceutical inhibition of USP7 by the small molecule P22077 attenuated PDAC cell growth and induced cell death in vitro and in vivo."
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"We observed that overexpression of USP7 enhances PDAC cell growth, which can be effectively inhibited by blocking glycolysis using 2-DG."
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"Moreover, the previous study showed that USP7 was elevated in GCC, and promoted CC cell growth and suppressed the sensitivity of cells to genotoxic insults by stabilizing MDC1 via deubiquitination (Su et al. 2018)."
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"This suggests that USP7 may enhance AML cell growth by activating mTOR [22]."
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"To test this idea, we transduced full-length plasmid of human ERα into MCF-7 cells and assessed the effect of ERα overexpression on cell growth inhibition induced by silencing USP7."
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"Functionally, USP7 overexpression promoted cell growth and invasion via deubiquitination of EZH2."
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"These results indicate that USP7 promotes cell growth in part through ERα stabilization ( Fig. 7 F)."
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"USP7 Inhibition Decreases Cell Growth and Viability in TP53 Wild-Type Neuroblastoma Cells."
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"USP7 inhibition can lead to cell growth arrest and apoptosis through inhibition of tumor promoters and stabilization of tumor suppressors , making it a promising druggable target for cancer therapy ."
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"Our finding that USP7 inhibition in vitro and in vivo significantly suppresses leukemic cell growth, alone and in combination with chemotherapy, independently of p53 status supports this notion."
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"USP7 silencing in MEC-1 cells abrogated cell growth, corroborating the bona fide data we obtained with the inhibitor."
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"Thirdly, knockdown of USP7 suppressed GC cell growth in vivo."
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"HAUSP strongly stabilizes p53 even in the presence of excess Mdm2, and also induces p53 dependent cell growth repression and apoptosis."
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"Inhibition of USP7 attenuates cell growth and induces cell death in PDAC."
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"The results suggest that USP7 promotes RMS cell growth and spread through increased SNAI2 expression.The potential link between USP7 and VM in RMS was also investigated."
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"USP7 depletion also led to significantly reduced cell growth compared to the parental cell lines (Figure 6A,B)."
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"Our results reveal that both knockdown and inhibition of Usp7 apparently block MB cell growth and migration, providing that Usp7 antagonists as potential drugs for MB clinical treatment."
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"Cell growth inhibition caused by USP7 inhibition was p53-dependent and occurred via the regulation of the MDM2-P53-P21 signalling pathway127.In the same year another series of PROTACs based on USP7 inhibitor scaffold was reported by Murgai et al. CST967 (104) appeared to be a highly potent degrader with growth-inhibitory activity in USP7-dependent cancer cells128."
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"As shown in Fig. 6B, knockdown of USP7 significantly enhanced the cell growth inhibition induced by SEL."
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"Interestingly , USP7 inhibitor suppressed cell growth in both GSI-sensitive ( CUTLL1 ) and GSI-resistant ( JURKAT , MOLT-4 , and CCRF-CEM ) T-ALL cells , thus providing a rationale for inclusion of USP7 inhibitors in a GSI-based regimens for treatment of T-ALL patients ."
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"We also show that USP7 and NOTCH1 bind T-ALL superenhancers, and inhibition of USP7 leads to a decrease of the transcriptional levels of NOTCH1 targets and significantly blocks T-ALL cell growth in vitro and in vivo."
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"Since NOTCH1 plays a significant role in T-ALL pathogenesis, we proposed that loss of function of USP7, which deubiquitinates and stabilizes ICN1, might inhibit T-ALL cell growth."
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"In conclusion, our findings indicate that pharmacological inhibition of USP7 impairs EBNA1 function and EBV‐driven cell growth, and that USP7 is an attractive candidate for EBV‐targeted therapy."
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"USP7 haploinsufficiency promotes T-ALL cellular growth."
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"These experiments showed that USP7 haploinsufficiency decreases the E protein activity of E2A and HEB and promotes T-ALL cell growth."
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"In this study, we demonstrated that loss of USP7 function inhibits cell growth by promoting cell cycle arrest and apoptosis in A375 and B16 cells."
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"High-throughput screening efforts led to the discovery of the first semi-specific, uncompetitive, and reversible inhibitor of USP7 (HBX 41,108), which was shown to stabilize p53 and inhibit cell growt[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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