IndraLab

Statements

CDYL decreases the amount of SCN8A. 4 / 4
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"Having established that CDYL inhibits SCN8A expression transcriptionally, we next examined whether and how CDYL regulates Nav1.6-mediated sodium currents and AP threshold in neuronal cells."
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"Consistent with the above demonstrated role of EZH2 in coordinating with CDYL in regulating SCN8A expression, reducing EZH2 expression in the hippocampus of transgenic mice over-expressing CDYL alleviated CDYL mediated changes of AP threshold, supporting the notion that CDYL coordinates with EZH2 to inhibit SCN8A expression and thus suppress intrinsic neuronal excitability."
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"These results probably reflect the dose dependent effect in which complete ablation of CDYL in a cell line more dramatically affect regional histone modification as compared to mild overexpression of CDYL in experimental animals, and demonstrate that change of regional H3K27me3 is the major underlying mechanism for CDYL repression of SCN8A expression."
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"Together, these results support an argument that CDYL inhibits SCN8A transcription mainly through recruiting H3K27me3 methyltransferase activity, possibly also the HDAC activity albeit to a less degree, to the intronic silencer of the gene."
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