IndraLab

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CASP14 inhibits BAP1. 1 / 1
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reach
"Mice with inactivated Bap1 developed simple cysts, atypical cysts and neoplastic nodules, with increased Ki-67 and carbonic anhydrase IX staining, supporting the notion that co-deletion of VHL and Bap1 in at least one allele is important for the pathogenesis of clear cell RCC, although the nature of the genetic interaction is not yet understood."