IndraLab

Statements

Kinase-active MTOR phosphorylates RPS6KB1 on serine. 3 / 3
3 |
bel
"mTOR stimulates protein synthesis by phosphorylating p70 S6 kinase (p70 S6K) and eIF4E binding proteins 1, 2, and 3 (4E-BPs). In turn, p70 S6K phosphorylates the ribosomal protein S6"
16288292
bel
"mTOR can control the mammalian translation machinery by direct phosphorylation and activation of p70 ribosomal S6 kinase (p70rsk)57, as well as phosphorylation of the initiation factor 4E for eukaryotic translation (eIF-4E) inhibitor, PHAS1 or 4E-binding protein 1 (ref. 58)."
11742412
bel
"TOR activity leads to phosphorylation and activation of ribosomal S6 kinase-1 (S6K1), and phosphorylation and inhibition of translation initiation factor eIF-4E binding protein-1 (4E-BP1)."
14607085