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UCHL1 activates cell population proliferation. 35 / 44
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"Restoring UCHL1 expression in silenced cell lines significantly inhibits their growth and colony formation ability, by inhibiting cell proliferation through cell cycle arrest in the G2/M phase and inducing apoptosis through the intrinsic caspase dependent pathway."
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"UCHL1 promotes in vitro clonogenicity, cell proliferation, and invasion."
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"In the present study, we explored role of UCH-L1 in the regulation of TNFalpha mediated VSMC proliferation in vitro."
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"Gain- and loss-of-function studies revealed that UCH-L1 enhances proliferation of multiple cell types, including human cancer cells."
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"Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin dependent kinases to enhance cell proliferation independently of its hydrolase activity."
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"UCH-L1 has been shown to stimulate proliferation in transformed lymphocytes and cervical carcinoma cells [XREF_BIBR, XREF_BIBR], while it promotes G1/S arrest in breast cancer cells [XREF_BIBR]."
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"UCHL1 inhibition reduced HGSOC cell proliferation and invasion as well as significantly decreased the in vivo metastatic growth of ovarian cancer xenografts."
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"Similarly, CCK-8 assay, scratch assay and transwell assay were applied to demonstrate that overexpression of UCHL1 promoted the proliferation, migration and invasion in SiHa, but when UCHL1 was knockdown in C-33A, the function of UCHL1 displayed the opposite result."
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"Conversely, inhibition of the UCHL1-HIF-1 pathway downregulated these malignancy related factors and also abolished UCHL1 mediated cell proliferation and invasiveness."
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"In contrast, mature tumors from both Emu-myc and Uchl1 and Emu-myc had a much higher proliferation rate that was not further enhanced by UCH-L1."
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"Other recent studies have found that UCHL1 could promote tumor cell proliferation and inhibit cell cycle arrest XREF_BIBR, which are involved in the development of chemoresistance in cervical cancer and pancreatic cancer XREF_BIBR, XREF_BIBR."
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"Indeed, using targeted siRNA to reduce cellular expression of UCHL1 in cultured cells, we show that UCHL1 promotes the proliferation and migration of human choroidal and retinal endothelial cells; UCHL1 specific knockdown resulted in significantly less proliferation and migration for 6 of 6 and 3 of 6 human choroidal or retinal endothelial cell isolates, respectively."
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"Silencing of UCH-L1 inhibited proliferation, colony formation of hilar cholangiocarcinoma cells in vitro and suppressed tumor growth of hilar cholangiocarcinoma cells in vivo."
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"Expression of a catalytically active UCH-L1 promoted the proliferation of a UCH-L1-negative EBV transformed lymphoblastoid cell line (LCL) and inhibited cell adhesion, whereas a catalytic mutant had no effect, confirming the requirement of UCH-L1 enzymatic activity for the regulation of these phenotypes."
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"Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Promotes Uterine Serous Cancer Cell Proliferation and Cell Cycle Progression."
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"Restoring UCHL1 expression in silenced cell lines significantly inhibited their growth and colony formation ability by inhibiting cell proliferation, causing cell cycle arrest in G2/M phase and inducing apoptosis through the intrinsic caspase dependent pathway."
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"Thus, one could imagine further improved nerve conduits based on silk with, e.g., binding of neuron specific protein gene product 9.5 (PGP 9.5) protein onto the silk to enhance Schwann cell migration and proliferation or loading the silk with chondroitinase ABC (ChABC) or glial cell derived neurotrophic factor (GDNF) to improve axonal regeneration."
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"Then, we found that knockdown of UCHL1 in osteosarcoma cell MG63 inhibited cell proliferation and significantly increased cell population in the G1 phase."
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"These data underscore the importance of the Akt pathway in malignant B-cells and provide precedence for the suggestion that UCH-L1 promotes the survival and proliferation of malignant B-cells through its effect on Akt signaling."
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"Knockdown of UCHL1 in OC cell lines promoted cell proliferation and reduced cell apoptosis [XREF_BIBR] UCHL1 also promotes prostate cancer metastasis through EMT induction [XREF_BIBR]."
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"Thus, the increased UCHL-1 levels in the aged SVZ may contribute to the declines in NSC and NPC proliferation with aging."
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"In contrast, recent evidence has also revealed that UCH-L1 enhances proliferation of multiple cell types, including Hela cells, Neuro2a cells, and human cancer cell lines H727 and MCF XREF_BIBR."
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"We find that UCH-L1 promotes proliferation and survival of lymphocytes in vitro and in vivo, at least in part, through its ability to boost Akt signaling."
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"UCHL1 promotes proliferation and metastasis in head and neck squamous cell carcinoma and could be a potential therapeutic target."
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"Overexpression of UCHL1 in MKN45 and BGC823 cells promoted cell proliferation, migration, and invasion depending on its de-ubiquitinase activity."
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"These findings demonstrated that UCHL1 promoted cell proliferation, migration, and invasion depending on its de-ubiquitinase activity by activating Akt and Erk1/2, which may account for its higher positive expression rate in liver metastases from gastric cancer."
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"Moreover, we show that pharmacological inhibition of UCHL1 blocks HSC proliferation and when administered in vivo acts in a therapeutic way to block progression of established fibrosis despite continu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"These data indicate that UCH-L1 promotes the survival and proliferation of transformed cells in a mechanism requiring de-ubiquitinase activity, but not its putative ligase activity."
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"This suggests that UCH-L1 increases the rate of proliferation in lymphocytes before the development of obvious tumors."
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"UCH-L1 increases lymphoid proliferation and decreases apoptosis in vivo."
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"UCH-L1 may accelerate the development of lymphoma by either increasing proliferation or reducing apoptosis in lymphocytes or in the resulting tumors."
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"In non small cell lung cancer and renal cell carcinoma, UCHL1 functions as an oncogene and promotes cell proliferation and migration [XREF_BIBR, XREF_BIBR]."
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"Here we show that knockdown of UCH-L1 by RNAi inhibits the proliferation of BL cells in suspension and semisolid agar and activates strong LFA-1-dependent homotypic adhesion."
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"The upregulated UCH-L1 in strain 5 NB promotes myoblast activation and proliferation during muscle regeneration and repair processes, while an increased NDPK may indicate the upregulation of DNA and protein synthesis in strain 5 NB because NDPK is an ubiquitous enzyme that catalyzes the transfer of the gamma -phosphate of a (deoxy) nucleoside triphosphate to a (deoxy) nucleoside diphosphate, and processes transcriptional regulation and protein histidine kinase activities."
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"We demonstrated that UCHL1 re-expression promoted the proliferation, migration and metastasis potential of HCT8 cells both in vitro and in vivo."
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