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UCHL1 activates cell population proliferation. 58 / 67
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"UCHL1 gene silencing limits the proliferation of endometrial cancer cells and delays the cell cycle [35]."
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"Our study therefore uncovered a novel amplification mechanism of HIF-2α signaling mediated by KDM4B in RCC.Functionally, we found that UCHL1 promoted RCC proliferation, migration, and angiogenesis in vitro and in vivo."
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"UCHL1 can prevent autophagy (autophagic cell death) and promote cell proliferation by inhibiting apoptosis [40]."
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"Upregulation of UCHL1 promoted NSC activation and proliferation by ubiquitin-proteasome approach-dependent protein aggregates clearance in vitro."
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"Results revealed that upregulation of UCHL1 (OE-UCHL1-LV) promoted NSC proliferation, which was abolished by LDN-57444 (Fig. 2G, H; Supplementary Fig. 2C, D)."
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"However, two other studies reported higher UCHL1 expression in liver metastases from GC and gastric cardiac adenocarcinoma, likely because UCHL1 overexpression increases the proliferation, migration, and invasion capabilities of GC cells [83,84]."
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"Interestingly, other research has unveiled that UCHL1 could enhance the proliferation of a range of cells, such as HeLa cells, Neuro2a cells, human cancer cell lines h727 and MCF (Ref."
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"On the other hand, over-expression of UCHL1 in lower-UCHL1-expression Saos2 cells dramatically induced cell proliferation and suppressed cell apoptosis."
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"Moreover, cell cycle analysis and up-regulation of cyclins showed that UCHL1 promoted cell proliferation by promoting G1/S cell cycle transition in osteosarcoma cells."
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"UCHL1 promotes proliferation and metastasis in head and neck squamous cell carcinoma and could be a potential therapeutic target."
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"Moreover, we show that pharmacological inhibition of UCHL1 blocks HSC proliferation and when administered in vivo acts in a therapeutic way to block progression of established fibrosis despite continu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Conversely, inhibition of the UCHL1-HIF-1 pathway downregulated these malignancy-related factors and also abolished UCHL1-mediated cell proliferation and invasiveness."
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"Thus, these results showed that UCHL1 had proliferation-promoting properties in osteosarcoma cells.As described above, how UCHL1 promotes proliferation remained unclear."
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"Knockdown of UCHL1 in OC cell lines promoted cell proliferation and reduced cell apoptosis [XREF_BIBR] UCHL1 also promotes prostate cancer metastasis through EMT induction [XREF_BIBR]."
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"Furthermore, our mechanistic studies have shown that UCHL1 elevates HIF activity through specific cleavage of degradative ubiquitin chains, elevates levels of pro-fibrotic gene expression and increases proliferation rates."
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"Some studies have suggested that UCHL1 enhances cell proliferation [40] and thus it might be involved in the abnormal growth of the prostate gland."
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"UCHL1 inhibition reduced HGSOC cell proliferation and invasion as well as significantly decreased the in vivo metastatic growth of ovarian cancer xenografts."
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"In conclusion, UCHL1 was confirmed to increase cell viability and proliferation as well as metastasis potential by stabilizing HIF‐1α to increase HIF‐1 activity in the spheroid 3D culture system.4 DISCUSSION."
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"Moreover, latest studies show that pharmacological inhibition of UCHL1 blocks hepatic stellate cells proliferation and when administered in vivo acts in a therapeutic way to block progression of estab[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"UCH-L1 has been shown to stimulate proliferation in transformed lymphocytes and cervical carcinoma cells [XREF_BIBR, XREF_BIBR], while it promotes G1/S arrest in breast cancer cells [XREF_BIBR]."
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"Indeed, using targeted siRNA to reduce cellular expression of UCHL1 in cultured cells, we show that UCHL1 promotes the proliferation and migration of human choroidal and retinal endothelial cells; UCHL1 specific knockdown resulted in significantly less proliferation and migration for 6 of 6 and 3 of 6 human choroidal or retinal endothelial cell isolates, respectively."
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"Thus, the increased UCHL-1 levels in the aged SVZ may contribute to the declines in NSC and NPC proliferation with aging."
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"Overexpression of UCHL1 in MKN45 and BGC823 cells promoted cell proliferation, migration, and invasion depending on its de-ubiquitinase activity."
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"Here we show that knockdown of UCH-L1 by RNAi inhibits the proliferation of BL cells in suspension and semisolid agar and activates strong LFA-1-dependent homotypic adhesion."
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"Other recent studies have found that UCHL1 could promote tumor cell proliferation and inhibit cell cycle arrest XREF_BIBR, which are involved in the development of chemoresistance in cervical cancer and pancreatic cancer XREF_BIBR, XREF_BIBR."
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"Expression of a catalytically active UCH-L1 promoted the proliferation of a UCH-L1-negative EBV transformed lymphoblastoid cell line (LCL) and inhibited cell adhesion, whereas a catalytic mutant had no effect, confirming the requirement of UCH-L1 enzymatic activity for the regulation of these phenotypes."
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"Higher expression of ubiquitin C-terminal hydrolase-L1 (UCHL1) in liver metastasis than in primary tissue could activate the ERK1/2 signaling, thus promoting the proliferation, migration, and invasion of GC cells (55)."
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"UCHL1 promotes the proliferation of porcine granulosa cells by stabilizing CCNB1."
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"The latest studies show that pharmacological inhibition of UCHL1 blocks hepatic stellate cells proliferation and when administered in vivo acts in a therapeutic way to block progression of established fibrosis despite continued liver injury [2]."
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"However, knockdown of UCHL1 or KLF5 could slow the proliferation of MDA-MB-468 xenograft tumors and also sensitize the tumors to Tamoxifen (Fig. 3A-C), without significant changes in body weight and cytotoxicity to the liver and kidney (Supplementary Fig. 5A-B)."
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"Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) Promotes Uterine Serous Cancer Cell Proliferation and Cell Cycle Progression."
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"Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin dependent kinases to enhance cell proliferation independently of its hydrolase activity."
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"We demonstrated that UCHL1 re-expression promoted the proliferation, migration and metastasis potential of HCT8 cells both in vitro and in vivo."
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"These findings demonstrated that UCHL1 promoted cell proliferation, migration, and invasion depending on its de-ubiquitinase activity by activating Akt and Erk1/2, which may account for its higher positive expression rate in liver metastases from gastric cancer."
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"UCH-L1 increases lymphoid proliferation and decreases apoptosis in vivo."
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"UCH-L1 may accelerate the development of lymphoma by either increasing proliferation or reducing apoptosis in lymphocytes or in the resulting tumors."
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"In contrast, mature tumors from both Emu-myc and Uchl1 and Emu-myc had a much higher proliferation rate that was not further enhanced by UCH-L1."
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"This suggests that UCH-L1 increases the rate of proliferation in lymphocytes before the development of obvious tumors."
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"Restoring UCHL1 expression in silenced cell lines significantly inhibited their growth and colony formation ability by inhibiting cell proliferation, causing cell cycle arrest in G2/M phase and inducing apoptosis through the intrinsic caspase dependent pathway."
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"These data indicate that UCH-L1 promotes the survival and proliferation of transformed cells in a mechanism requiring de-ubiquitinase activity, but not its putative ligase activity."
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"The upregulated UCH-L1 in strain 5 NB promotes myoblast activation and proliferation during muscle regeneration and repair processes, while an increased NDPK may indicate the upregulation of DNA and protein synthesis in strain 5 NB because NDPK is an ubiquitous enzyme that catalyzes the transfer of the gamma -phosphate of a (deoxy) nucleoside triphosphate to a (deoxy) nucleoside diphosphate, and processes transcriptional regulation and protein histidine kinase activities."
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"Specifically, in gastric cancer, it has been revealed that overexpression of UCHL1 increases cell proliferation, migration, and invasion by activating the AKT and ERK1/2 tumor growth pathways, a phenomenon dependent on the enzymatic activity of UCHL1 (Gu et al., 2015)."
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"Thus, one could imagine further improved nerve conduits based on silk with, e.g., binding of neuron specific protein gene product 9.5 (PGP 9.5) protein onto the silk to enhance Schwann cell migration and proliferation or loading the silk with chondroitinase ABC (ChABC) or glial cell derived neurotrophic factor (GDNF) to improve axonal regeneration."
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"We find that UCH-L1 promotes proliferation and survival of lymphocytes in vitro and in vivo, at least in part, through its ability to boost Akt signaling."
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"UCHL1 overexpression promoted GC proliferation, and knockdown had the opposite effect."
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"These data underscore the importance of the Akt pathway in malignant B-cells and provide precedence for the suggestion that UCH-L1 promotes the survival and proliferation of malignant B-cells through its effect on Akt signaling."
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"In the present study, we explored role of UCH-L1 in the regulation of TNFalpha mediated VSMC proliferation in vitro."
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"In contrast, recent evidence has also revealed that UCH-L1 enhances proliferation of multiple cell types, including Hela cells, Neuro2a cells, and human cancer cell lines H727 and MCF XREF_BIBR."
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"UCHL1 promoted the proliferation of porcine GCs by stabilizing CCNB1, and isovitexin enhanced the enzyme activity of UCHL1."
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"As expected, CCK-8 assays demonstrated that cell proliferation was prominently suppressed by UCHL1 depletion in UCHL1 (786-O, SLR-23) cells, which could be completely rescued by WT UCHL1 (Fig. 2D)."
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"Wen et al. [24] studies had shown that TGF-β1 could promote PGP9.5 expression in CAFs to enhance colorectal cancer cell proliferation via the ERK1/2 and PI3K signaling pathways."
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"Silencing of UCH-L1 inhibited proliferation, colony formation of hilar cholangiocarcinoma cells in vitro and suppressed tumor growth of hilar cholangiocarcinoma cells in vivo."
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"In non small cell lung cancer and renal cell carcinoma, UCHL1 functions as an oncogene and promotes cell proliferation and migration [XREF_BIBR, XREF_BIBR]."
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"Gain- and loss-of-function studies revealed that UCH-L1 enhances proliferation of multiple cell types, including human cancer cells."
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"Restoring UCHL1 expression in silenced cell lines significantly inhibits their growth and colony formation ability, by inhibiting cell proliferation through cell cycle arrest in the G2/M phase and inducing apoptosis through the intrinsic caspase dependent pathway."
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"Similarly, CCK-8 assay, scratch assay and transwell assay were applied to demonstrate that overexpression of UCHL1 promoted the proliferation, migration and invasion in SiHa, but when UCHL1 was knockdown in C-33A, the function of UCHL1 displayed the opposite result."
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"UCHL1 promotes in vitro clonogenicity, cell proliferation, and invasion."
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"However, over-expression of UCHL1 in lower-UCHL1 expression cell line Saos2 increased cell proliferation rate compared with corresponding control ( Fig. 3D and F )."
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