IndraLab

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ZUP1 inhibits SGCG. 4 / 4
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"For example, viral DUB activity of CCHFV OTU and equine arteritis virus OTU suppresses type I IFN signaling during infection (7) (8) (9) , whereas the turnip yellow mosaic virus DUB counters Ub-mediated proteasomal degradation of its polymerase (17) ."
31337717
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"One such multifunctional domain is the coronavirus papain-like protease (PLP), which processes the viral replicase polyprotein, has deubiquitinating (DUB) activity, and antagonizes the induction of type I interferon (IFN)."
20181693
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"In particular, the DUB and deISGylating activities encoded by nsp3 suppress the induction and signaling of type I interferons.The functional implication of PTMs on many coronavirus proteins has not been fully characterized, and their biological significance requires further investigations combining reverse genetics and suitable in vivo models."
32201497
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"For example, viral DUB activity of CCHFV OTU and equine arteritis virus OTU suppresses type I IFN signaling during infection (7–9), whereas the turnip yellow mosaic virus DUB counters Ub-mediated proteasomal degradation of its polymerase (17)."
31337717