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Binding inhibits ATXN3. 1 / 1

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"Zhou and colleagues found that the small ubiquitin-like modifier-1 ( SUMO-1 ) stablized mutant ataxin-3 through K166 binding and thereby increased neurotoxicity [ 72 ] , while Hwang and Lee reported that SUMO-1 binding promotes degradation of ataxin-3 with polyglutamine expansion through enhanced autophagy [ 73 ] ."

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IndraLab

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Binding inhibits ATXN3. 1 / 1

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