IndraLab

Statements

CALM inhibits KCNQ4. 4 / 4
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eidos
"Mutations in the Kv7.4 S2-S3 loop decreased Ca2 + / CaM binding as well as Ca2 + / CaM inhibition on channel activation , while these mutations had no effect on CaM3 binding as well as activation of Kv7.4 co-expressed with CaM3 , suggesting that Ca2 + / CaM inhibited Kv7.4 activation through an interaction with the Kv7.4 S2-S3 loop ."
33551832
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"Coexpression of CaM in Chinese hamster ovary (CHO) cells strongly reduced currents of KCNQ2, KCNQ4, and KCNQ5, but not KCNQ1 or KCNQ3."
15901836
eidos
"Taken together , our results proved that CaM regulates Kv7.4 channels in a calcium-dependent manner , in which Apo / CaM facilitated Kv7.4 activation and Ca2 + / CaM inhibited Kv7.4 activation ."
33551832
reach
"Moreover, overexpression of CaM reduced current amplitudes of KCNQ2, KCNQ4, and KCNQ5, but not those of KCNQ1 and KCNQ3."
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