IndraLab

Statements

CALM inhibits KCNQ4. 4 / 4
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reach
"Coexpression of CaM in Chinese hamster ovary (CHO) cells strongly reduced currents of KCNQ2, KCNQ4, and KCNQ5, but not KCNQ1 or KCNQ3."
15901836
reach
"Moreover, overexpression of CaM reduced current amplitudes of KCNQ2, KCNQ4, and KCNQ5, but not those of KCNQ1 and KCNQ3."
23087646
eidos
"Taken together , our results proved that CaM regulates Kv7.4 channels in a calcium-dependent manner , in which Apo / CaM facilitated Kv7.4 activation and Ca2 + / CaM inhibited Kv7.4 activation ."
33551832
eidos
"Mutations in the Kv7.4 S2-S3 loop decreased Ca2 + / CaM binding as well as Ca2 + / CaM inhibition on channel activation , while these mutations had no effect on CaM3 binding as well as activation of Kv7.4 co-expressed with CaM3 , suggesting that Ca2 + / CaM inhibited Kv7.4 activation through an interaction with the Kv7.4 S2-S3 loop ."
33551832