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Statements


USP7 activates POLQ. 1 / 1
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reach
"Considering that aberrant USP7 expressions were frequently found in various tumors and elevated TLS is involved in resistance to chemotherapeutic agents, our findings that USP7 mediated stabilization of Poleta facilitates PCNA monoubiquitination mediated stress-tolerance pathways provide unique mechanistic insights for USP7 related tumorigenesis and may be useful for developing future therapeutic strategy."