IndraLab

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USP15 deubiquitinates TRIM25. 13 / 13
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"The sfRNA of an epidemic DENV strain bound to TRIM25 in a sequence specific manner, and this interaction prevented TRIM25 deubiquitination and stabilization by USP15, thereby blunting the RIG-I-mediated IFN response [XREF_BIBR]."
27792906
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"Furthermore, wild-type USP15, but not its catalytically inactive C783A mutant, decreased the polyubiquitylation of TRIM25 that was caused by ectopically expressed HOIL-1L and HOIP (XREF_FIG)."
24399297
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"The protein levels of TRIM25 may also have to be at a certain level in order for it to productively ubiquitinate RIG-I, as the ubiquitin protease USP15 deubiquitinates TRIM25 at later time points in viral infection (109)."
31379819
ubibrowser
"Review"
27775833
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"Conversely, USP15 and USP4 deubiquitinate TRIM25 and RIG-I, respectively, to stabilize the proteins."
25644461
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"USP15 was originally identified as a DUB enzyme that interacts with TRIM25, serving to cleave the K48-ubiquitin chain that maintains TRIM25 in an inactive state; thus, de-ubiquitination of TRIM25 by USP15 potentiates TRIM25 dependent activation of RIG-I [XREF_BIBR]."
28295214
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"We found that upon binding to TRIM25, USP15 deubiquitylated TRIM25, which stabilized the protein and thereby led to a sustained RIG-I-dependent antiviral response (XREF_FIG)."
24399297
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"We next addressed whether USP15 deubiquitylated endogenous TRIM25 in the context of viral infection."
24399297
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"In contrast, USP15 deubiquitylates TRIM25, preventing the LUBAC dependent degradation of TRIM25 [XREF_BIBR]."
33498196
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"A study has demonstrated that USP15 deubiquitinates TRIM25, thus counteracting the LUBAC dependent degradation of TRIM25."
33511009
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"For instance, USP15 interacts with and deubiquitinates TRIM25 when it is ubiquitinated by the E3 complex LUBAC."
25651846
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"USP15 deubiquitylates TRIM25."
24399297
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"Further, RIG-I can be ubiquitinated and activated by TRIM25, which, in turn, can be ubiquitinated and degraded by LUBAC (linear ubiquitin chain assembly complex) and deubiquitinated and stabilized by USP15 (XREF_FIG)."
26454188