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"Mutations in KCNE2 and/or KCNQ1 have previously been associated with LQTS, AF, and even early-onset myocardial infarction ( xref ; xref ; xref ; xref ; xref ), each of which is also predisposed to by thyroid dysfunction in the general population ( xref ; xref ; xref ), suggesting the intriguing possibility of an endocrine component to some KCNE2- and KCNQ1-associated human cardiac disease."