IndraLab

Statements

EGF bound to EGFR activates ERK. 5 / 5
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"In primary hepatocyte cultures, EGF or TGFalpha binding to EGF receptor activates Erk1/2 and PI3K pathways, induces cyclin D1 and thus initiates DNA synthesis."
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"In addition, ERK activities can also be induced by EGF/EGFR interaction."
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"The released EGF binds to the EGFR to activate AKT and ERK 1/2."
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"In the absence of cetuximab (XREF_SUPPLEMENTARY), EGF binds to EGFR and activates the AKT and ERK signalling pathways, which are involved in cell survival and proliferation."
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"In RTCs, binding of EGF to EGFR stimulates activities of ERK, phospholipase C (PLC), and SphK, resulting in increased intracellular levels of S1P, while the EGF and EGFR mediated Ca 2+ mobilization, which may regulate apoptosis, requires activation of PLC and SphK in HEK293 cells [XREF_BIBR]."
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