IndraLab
Statements
reach
"Additionally, to evade host innate immunity, Hr-HPV can inhibit PRR signaling through the induction of ubiquitin C-terminal hydrolase L1 (UCHL1) expression; UCHL1 blocks the activation of NF-kappaB and IRF3, both of which are transcription factors that induce the production of proinflammatory cytokines and chemokines XREF_BIBR."
reach
"The importance of K63 linked ubiquitination for TRAF3 dependent signaling was strengthened by the identification of several DUBs removing the K63 linked ubiquitination from TRAF3 : the deubiquitinating enzyme A (DUBA), OTUB1, as well as the ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) that is specifically subverted by high-risk human papillomaviruses to downregulate IRF3 activation and PRR responses [XREF_BIBR, XREF_BIBR - XREF_BIBR]."