IndraLab

Statements

RHEB bound to GTP activates MTOR. 7 / 7
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"The main conclusion of our study is that RGS10 suppression causes an increase in activated, GTP bound Rheb and results in mTOR pathway activation among ovarian cancer cells."
26319900
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"Rheb when associated with GTP stimulates mTOR activity [XREF_BIBR]."
18654857
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"PI3K and Akt signaling suppresses the activity of the Rheb GTPase activating complex (TSC1 and TSC2) and thereby increases the level of GTP bound Rheb, which in turn induces mTOR signaling [XREF_BIBR]."
21314915
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"GTP bound Rheb activates the mTOR kinase activity."
26299971
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"Therefore, the sequestration of TSC2 with 14-3-3 increases the relative amount of GTP bound Rheb and this activates mTOR in muscle cells XREF_BIBR."
22682632
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"Moreover, activation of Akt has been reported to inactivate the TSC1/2 complex, leading to increased active GTP bound Rheb, which activates mTOR XREF_BIBR."
27313493
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"In this case, GTP bound RHEB activates mTOR."
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