IndraLab

Statements

Itgal activates COPS5. 2 / 2
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"Engagement of LFA-1 causes dissociation of JAB1 from LFA-1 with a concomitant increase in the nuclear pool of JAB1, leading to formation of c-Jun complexes and activation of AP-1 transcriptional responses."
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"For example, LFA-1 engagement activates the beta2-integrin-associated c-Jun cofactor JAB1, resulting in its translocation to the nucleus where it enhances AP-1-mediated transactivation [58]."
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