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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Itgal activates COPS5. 2 / 2

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"Engagement of LFA-1 causes dissociation of JAB1 from LFA-1 with a concomitant increase in the nuclear pool of JAB1, leading to formation of c-Jun complexes and activation of AP-1 transcriptional responses."

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"For example, LFA-1 engagement activates the beta2-integrin-associated c-Jun cofactor JAB1, resulting in its translocation to the nucleus where it enhances AP-1-mediated transactivation [58]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...