IndraLab
Statements
Phosphatidylinositol phosphate inhibits KCNH1. 10 / 10
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"The PIP 2 inhibition of hEAG1 channels is physiologically relevant as evidenced by the observation that neuronal transmitter 5-HT noticeably increased the whole-cell current from the hEAG1 channels coexpressed with the serotonin receptor HTR 2A in HEK293 cells, suggesting that endogenous PIP 2 may exert a detectable tonic inhibitory influence on hEAG1 channels in intact neurons."
reach
"We found that depletion of endogenous PIP 2 by activation of the voltage sensing phosphatase from Danio rerio (Dr-VSP) or the human muscarinic type-1 receptor (hM1R) inhibits hEAG1 currents; however, the application of exogenous PIP 2 to increase the level of this lipid on the plasma membrane, also induced an inhibition of hEAG1."
sparser
"The PIP 2 inhibition of hEAG1 channels is physiologically relevant as evidenced by the observation that neuronal transmitter 5-HT noticeably increased the whole-cell current from the hEAG1 channels coexpressed with the serotonin receptor HTR 2A in HEK293 cells, suggesting that endogenous PIP 2 may exert a detectable tonic inhibitory influence on hEAG1 channels in intact neurons."
sparser
"The PIP 2 inhibition of hEAG1 channels is physiologically relevant as evidenced by the observation that neuronal transmitter 5-HT noticeably increased the whole-cell current from the hEAG1 channels coexpressed with the serotonin receptor HTR 2A in HEK293 cells, suggesting that endogenous PIP 2 may exert a detectable tonic inhibitory influence on hEAG1 channels in intact neurons."
reach
"Physiological relevance of the tonic inhibitory influence of PIP 2 as an endogenous modulator of hEAG1 is further suggested by the finding that activation of serotonin HTR 2A receptors, known to activate PLC XREF_BIBR to promote hydrolysis of PIP 2, also increases hEAG1 currents at negative voltages."