IndraLab

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Phosphatidylinositol phosphate inhibits KCNH1. 11 / 11
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"The PIP 2 inhibition of hEAG1 channels is physiologically relevant as evidenced by the observation that neuronal transmitter 5-HT noticeably increased the whole-cell current from the hEAG1 channels coexpressed with the serotonin receptor HTR 2A in HEK293 cells, suggesting that endogenous PIP 2 may exert a detectable tonic inhibitory influence on hEAG1 channels in intact neurons."
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"The PIP 2 inhibition of hEAG1 channels is physiologically relevant as evidenced by the observation that neuronal transmitter 5-HT noticeably increased the whole-cell current from the hEAG1 channels coexpressed with the serotonin receptor HTR 2A in HEK293 cells, suggesting that endogenous PIP 2 may exert a detectable tonic inhibitory influence on hEAG1 channels in intact neurons."
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"Second, an increase in plasma membrane PIP 2 by its direct application to excised inside-out membrane patches also induced an inhibition of hEAG1 ( Fig. 4 A–C), which indicate that PIP 2 is acting as [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Molecular determinants of hEAG1 channel inhibition by PIP 2 ."
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"Inhibition of hEAG1 channels by PIP 2."
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"Molecular determinants of hEAG1 channel inhibition by PIP 2 ."
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"The PIP 2 inhibition of hEAG1 channels is physiologically relevant as evidenced by the observation that neuronal transmitter 5-HT noticeably increased the whole-cell current from the hEAG1 channels coexpressed with the serotonin receptor HTR 2A in HEK293 cells, suggesting that endogenous PIP 2 may exert a detectable tonic inhibitory influence on hEAG1 channels in intact neurons."
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"In this case, PIP 2 inhibits hEAG1 channels through a mechanism that requires an intact CaM BD-N region."
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"PIP 2 quickly inhibited the hEAG1 channel when the membrane potential was held at 40mV (XREF_FIG, D)."
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"Physiological relevance of the tonic inhibitory influence of PIP 2 as an endogenous modulator of hEAG1 is further suggested by the finding that activation of serotonin HTR 2A receptors, known to activate PLC XREF_BIBR to promote hydrolysis of PIP 2, also increases hEAG1 currents at negative voltages."
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"Recently, exogenously applied PIP 2 was reported to inhibits hEAG1 channels [ 13 ]."
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