IndraLab

Statements

USP14 binds foci. 5 / 5
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"Next, to confirm whether the nuclear foci formed by USP14 in response to IR are DSB associated we did a co-localization analysis of USP14 with γH2AX, which is a gold-standard marker of DSBs [ xref , xref ], using co-immunostaining and confocal microscopic analysis."
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"IR treatment, indeed, induced USP14 foci formation in a time-dependent manner in H460 and A549 NSCLC cells, respectively ( xref A,B), similar to what we have previously shown in PCa cells [ xref , xref ]."
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"In contrast, LNCaP and -C4-2 cells with ectopic expression of GFP-PTEN (PTEN+) showed significantly reduced USP14 foci formation in response to IR ( xref )."
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"As shown above, we found that IR-treatment induced USP14 foci formation in a time-dependent manner."
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"Immunostaining and confocal microscopy was used to investigate IR-induced foci (IRIF) formation by USP14."
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