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USP14 activates apoptotic process. 53 / 54
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"The overexpression of USP14 in USP14 low expression cell lines promoted cell proliferation and migration, whereas USP14 downregulation suppressed tumor cell proliferation, decreased tumor cell colony number, increased apoptosis rate, and decreased cell migration and invasion."
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"The combination of enzalutamide, a nonsteroidal antiandrogen, with either knockdown or pharmacological inhibition of USP14 promotes arrest of cell cycle progression and induces apoptosis (Xia et al. 2019)."
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"GA Effectively Reduced TGT-Induced Hepatocyte Apoptosis."
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"Finally, we performed TUNEL staining, and the results showed that USP14 inhibition prevented neuronal apoptosis after MCAO (Figure 5E,F, p = 0.0001 and p = 0.0026)."
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"Targeting USP14 and UCHL5 by small compounds has been shown to overcome bortezomib resistance and induce apoptosis in multiple myeloma ( Tian et al., 2014 )."
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"Together, it was suggested that SPAG5‐AS1 stabilized SPAG5 protein through interacting with USP14 in HG‐treated HPCs, and that USP14 and AKT/mTOR formed a positive feedback loop.3.7 SPAG5-AS1 promoted apoptosis and attenuated autophagy in HG-treated HPCs through SPAG5/AKT/mTOR pathway."
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"For example, TgT stimulated apoptosis and inhibited IL-8 production in adult, but not neonatal cells."
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"Consistent with previous study, our study demonstrated that USP14 knockdown attenuated OGD/R treatment mediated the enhancement effect on SK-N-SH cell inflammation, apoptosis, and ferroptosis, indicating that USP14 accelerates the progression of stroke.Ferroptosis is a mechanism of cell death after ischemia in many organs, such as the kidney and heart."
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"Downregulation of USP14 may suppress cell proliferation, migration, and promote cell apoptosis via stabilizing AR in prostate cancer or AR-positive BCa (16, 25)."
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"Furthermore, pharmacological targeting of USP14 with inhibitor IU1 or knockdown using shRNA stabilizes ARs, enhances the sensitivity of HR+ BCa cells to AR antagonist Enzalutamide, and, in turn, enhances TNBC cell apoptosis [72]."
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"Of note, we found that USP14-mediated apoptosis was mainly dependent on autophagy in OSCC cells with IR exposure.USP14 suppression significantly reduced the tumor growth in OSCC mouse model with IR ex[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Therefore, our current research may allow targeting UCHL5 and USP14 in 19S regulatory particle for anti-cancer drug development.b-AP15 was reported to inhibit tumor cell growth and induce cell apoptosis, and displays anti-tumor role in multiple tumor cell models without inhibiting 26S proteasomes proteolytic activities."
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"Downregulating USP14 induced inhibitory effects in EC cells by promoting apoptosis."
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"The results revealed that USP14 knockdown repressed the colony-forming ability of HEC-1-B and SNG-M cells and enhanced apoptosis (vs. the vector group, Figure 4B, 4C)."
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"USP14 can modulate the progression of multiple different kinds of tumors, including OSCC, through mediating cancer cell proliferation, apoptosis and cell cycle arrest [ 8–10 ]."
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"Furthermore, both genetic and pharmacological inhibition of USP14 significantly suppressed the growth of AR-reactive breast cancer cells by impeding the G0/G1-S phase transition and inducing apoptosis [19]."
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"Together, reducing USP14 could enhance DNA damage and apoptosis to improve the radiosensitivity of OSCC cells.Autophagy is considered as a double-edged sword in regulating radioresistance, which is as[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Selective USP14 and UCHL5 inhibitor b-AP15, induced apoptosis in MM cell lines and in primary MM cells via downregulation of cell division cycle 25C (CDC25C), CDC2, and cyclin-B1, as well as the activation of caspases and unfolded protein response pathways (p-IREalpha, p-eIF2alpha, and CHOP)."
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"Altogether, these findings demonstrated that USP14 suppression-reduced radioresistance was at least in part by the modulation of autophagy.Autophagy and apoptosis are both important physiological proc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"We previously confirmed that a specific USP14 and UCH37 inhibitor b-AP15 4 inhibited tumor cell growth and induced apoptosis and in vitro (data not shown)."
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"Our recent study exemplifies the feasibility of such an approach : specifically, we showed that blockade of 19S associated DUBs USP14 and UCHL5 with a small-molecule inhibitor (bAP15 and VLX1570) induces apoptosis in MM cells and overcome bortezomib resistance, with a favorable toxicity profile."
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"To further investigate the morphological changes induced by TGT in osteosarcoma cells undergoing apoptosis, we observed the cell morphology under an inverted microscope after 48 h of treatment."
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"Hence, USP14, SPARC5-AS1, SPARC5, and Akt form a positive feedback loop that leads to the apoptosis of podocytes under diabetic conditions [147]."
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"Interestingly, TgT by itself stimulated apoptosis, but only in adult cells."
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"The results of APC Annexin V/7-AAD double staining showed that TGT induced apoptosis in a dose-dependent manner in 143B and SAOS2 cells at concentrations of 25, 50, and 75 mg/mL (Fig. 10A and B)."
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"TGT-induced mitochondrial apoptosis in osteosarcoma cells."
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"This indicates that TGT can induce tumor cell apoptosis by disrupting the stability of the mitochondrial membrane."
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"TGT modulated apoptosis-related protein activity in osteosarcoma cells."
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"The molecular mechanism of TGT-induced apoptosis in osteosarcoma cells was demonstrated by in vitro experiments."
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"Moreover, the expression of several S100 isoforms (including S100a4, S100a6, S100a8, and S100a9) has increased pro-inflammatory and pro-fibrotic activities [20] in all endothelial cell subtypes under TGT stimulation.3.4 TGT treatment caused marked inflammatory response, apoptosis, and fatty acid metabolism dysfunction in hepatocytes."
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"Additionally, both genetic and pharmacological inhibition of USP14 significantly suppressed cell proliferation in AR responsive breast cancer cells by blocking G 0 / G 1 to S phase transition and inducing apoptosis."
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"In summary, TGT treatment induced the apoptosis of hepatocytes and positively regulated inflammation.3.5 TGT treatment significantly activated HSCs."
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"For example, USP14 is related to the malignant transformation of hepatocytes and promotes hepatocellular carcinoma development by increasing cell proliferation, altering the cell cycle and reducing apoptosis [6]."
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"This suggests that TGT may induce mitochondrial apoptosis in osteosarcoma cells."
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"Consistent with the results of network pharmacology, biological experiments have demonstrated that TGT can induce morphological changes and mitochondrial apoptosis in osteosarcoma cells."
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"They may be associated with TGT-induced apoptosis in osteosarcoma.To test this hypothesis further, we performed in vitro pharmacological experiments using TGT in osteosarcoma cells."
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"Flow cytometry instrument and MMP detection results show that the TGT can induce osteosarcoma cells induced apoptosis dose-dependently."
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"Similar results were observed in HN6 cells after USP14 knockdown, also demonstrating that USP14 knockdown with specific shRNA was able to significantly reduce the apoptosis induced by b-AP15."
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"Together, this confirmed that USP14 knockdown could resist OSCC cell apoptosis induced by b-AP15 treatment, which indicated that USP14 might be involved in b-AP15-induced apoptosis, further demonstrat[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"TGT was shown to dramatically suppress the proliferation, migration and invasion, and induce apoptosis of osteosarcoma 143B and MG-63 cells in vitro."
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"The expression of ER stress-associated proteins including ATF6, BiP, p-IRE1, XBP1s and CHOP, as well as apoptosis-associated cleaved caspase-3 and cleaved PARP1 proteins, was significantly upregulated by TGT treatment in osteosarcoma 143B cells, suggesting that TGT might promote the apoptosis of osteosarcoma 143B cells through the IRE1/CHOP pathway."
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"Knockdown of USP14 with the lentiviral vector delivery of shRNA in human hepatocarcinoma SMMC7721 cells suppressed cell proliferation, altered the cell cycle and induced cell apoptosis."
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"Importantly, TGT led to a marked increase in the apoptosis score (Figs."
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"In addition, b-AP15, a novel inhibitor of USP14, selectively blocks the deubiquitylating activity of USP14, decreases viability and inhibits proliferation of MM cells, which is associated with growth [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In this study, we found that TGT treatment led to hepatocyte apoptosis in the major subtype of Hep1 with the primary functions of regulating fatty acid and amino acid metabolism."
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"GA could inhibit TGT-induced apoptosis in BRL-3A cells."
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"USP14 promotes tumorigenesis and chemoresistance in multiple myeloma by suppressing apoptosis [45]."
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"GA could mitigate TGT-induced acute liver injury by mediating PKM2, reducing oxidative stress and inflammation and reducing hepatocyte apoptosis."
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"The PPAR-gamma agonist TgT attenuated MEHP mediated suppression of apoptosis and stimulation of oxidative metabolism by neonatal neutrophils."
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"In renal epithelial cells subjected to hypoxia/reoxygenation (H/R), Usp14 knockdown increased cell viability and reduced apoptosis."
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"Furthermore, TGT and TP modulate PKA, PI3K-AKT, NF-κB, and apoptosis-related signaling pathways, contributing to the reducing inflammation, apoptosis and demyelination in EAE mice."
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"Taken together, these data revealed that USP14 depletion inhibited HNSCC proliferation and metastasis and increased HNSCC apoptosis in vitro."
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"Functional experiments showed that si-USP14 offset OGD/R treatment-induced suppression of cell proliferation and enhancement of apoptosis rate [Figure 2b-d]."
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