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PSMD14 decreases the amount of GRB2. 4 / 4
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"Additionally, the ubiquitination level of GRB2 was significantly increased by depletion of PSMD14."

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"Moreover, an in vivo ubiquitination assay validated that the ubiquitination level of GRB2 was significantly increased by PSMD14 silencing ( Fig. 4 G), thereby protecting GRB2 from degradation."

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"The knockdown of PSMD14 accelerated the degradation of GRB2 protein, whereas PSMD14 overexpression could strikingly extend the half-life of GRB2 protein levels."

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"It was observed that knockdown of PSMD14 accelerated the degradation of GRB2 protein in MHCC-97h cells ( Fig. 4 E), whereas PSMD14 overexpression could strikingly extend the half-life of GRB2 protein [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"