IndraLab

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KCNMA1 activates PAGR1. 4 / 4
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"As measured by LIVE and DEAD immunofluorescent staining, we found that administration of RBC nanosponges allowed a significant increase in survival of keratinocytes upon coincubation of the cells with the WT SLO producing GAS strain at MOI = 25 (50% survival vs. 20% untreated, Figure XREF_FIG)."
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"We then tested the ability of RBC derived nanosponges to block hemolysis induced by coincubation of freshly isolated human RBC with a high level SLO producing WT GAS strain compared to its isogenic DeltaSLO mutant as a control."
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"SLO promotes GAS resistance to phagocyte killing and impairs critical phagocyte functions such as oxidative burst, migration, degranulation and neutrophil extracellular trap (NET) production."
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"We injected the invasive WT SLO producing GAS strain subcutaneously into the flanks of WT C57bl6 mice and then subsequently treated the mice proximally with either vehicle only control or vehicle + 50 mg/kg of RBC nanosponges at 15 min post-infection, a dose known to be well tolerated by mice in studies of purified alpha-toxin neutralization."
28769806