IndraLab

Statements

CACNA1A inhibits FOXH1. 24 / 24
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"Likewise, intracellular protease application has been shown to produce strong stimulation of VGCCs and a partial loss of fast voltage-dependent inactivation, which has been linked to C-terminal cleavage of a conserved autoinhibitory region in the pore-forming Ca v α 1 subunit ( xref ; xref ; xref ; xref )."
29453293
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"Furthermore, AA regulates the inactivation process in other Kv channels, introducing a fast voltage-dependent inactivation in non-inactivating Kv channels."
22973228
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"HERG has fast voltage-dependent inactivation, relatively slow deactivation, and fast recovery from inactivation."
21806931
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"However, the prototypical model for voltage-dependent inactivation remains the “ball-and-chain model,” first designed to account for fast voltage-dependent inactivation in Na + channels ( Armstrong a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
9746514
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"One confounding issue is a potential interplay between calcium- and voltage-dependent properties, such as the consequences of a Ca 2+ –CaM-binding site identified in the III–IV linker of Na v 1.5 sodium channels, which is also the region responsible for the fast voltage-dependent inactivation within sodium channels ( xref , xref , xref )."
28972185
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"The mutant FHF1 proteins had a strong gain-of-function phenotype in transfected Neuro2A cells, enhancing the depolarizing shifts in Nav1.6 voltage-dependent fast inactivation, predicting increased neuronal excitability."
27164707
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"In summary, data in xref and xref indicate that the hERG channel displayed its unique fast voltage-dependent inactivation and recovery from inactivation when a K + -free, 135 mM Na + pipette solution was used."
16769794
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"The kinetic hallmark of T-type channels is slow activation and fast voltage-dependent inactivation."
20951705
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"The constructed model could closely reproduce the experimental Ba2+ and Ca2+ current results under basal condition where no beta-stimulation was added after a slight reduction of the development of fast voltage-dependent inactivation with depolarization."
17822746
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"As stated above, it has been described that AA regulates the inactivation process in other potassium channels, introducing a fast voltage-dependent inactivation into non-inactivating Kv channels (Oliver et al., xref )."
22973228
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"T-channels require a smaller depolarization for opening, exhibit relatively fast voltage-dependent inactivation and at resting membrane potential there is a small fraction of channels available for opening to form so called “window” currents ( xref )."
29468189
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"Both channels are characterized by fast voltage-dependent inactivation; the cytoplasmic N-terminus has a positively charged ball that provokes the fast closing of the channel by occluding the pore once it is opened xref ."
28522852
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"Gbeta1 and Gbeta2 strongly mimicked the fast voltage-dependent inhibition of calcium channels produced by many G-protein-coupled receptors."
9801356
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"The fast voltage-dependent inactivation limits outward current through the channel at positive voltages and thus helps maintain the action potential plateau phase that controls contraction and prevents premature excitation."
16769794
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"Our data further showed that the hERG Na + current displayed an inactivation that is different from the well documented fast voltage-dependent hERG inactivation."
16769794
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"This mutation is known to disrupt fast voltage-dependent hERG inactivation but retains high K + selectivity ( xref ; xref )."
16769794
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"Our data suggest that the isradipine-induced acceleration of the Ca(v)1.2 current decay reflects enhanced fast voltage-dependent inactivation and not open channel block."
11487504
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"The mutations also disabled FHF modulation of voltage-dependent fast inactivation of sodium channels in neuronal cells."
19406745
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"The well documented fast voltage-dependent inactivation of the hERG K + current may represent the I P , but I C has not been described possibly because it is prevented by external K + ions."
16769794
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"We have demonstrated that the hERG channel displayed its unique fast voltage-dependent inactivation and recovery from inactivation when a K + free, Na + rich intracellular solution was used ( xref and xref )."
16769794
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"In addition to the fast voltage-dependent inhibition by Mg 2+ , intracellular Mg 2+ ions have been shown to induce a further, slow inactivation of TRPV5/6 channels [ xref , xref ], which could be reversed by increasing PIP 2 levels in the plasma membrane [ xref ]."
25106481
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"These channels are activated at negative membrane potentials and show a fast voltage-dependent inactivation with respect to other VSCCs."
28290248
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"To study isradipine effects on I(Ba) decay without contamination by intrinsic inactivation we expressed a mutant (V1504A) lacking fast voltage-dependent inactivation."
11487504
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"T-type VDCCs reach their peak conductance at -30 mV and undergo fast voltage-dependent inactivation, which is half-maximal at -65 mV. xref Differences between the roles VDCCs play in mouse and human β cells are illustrated in xref and xref ."
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