IndraLab

Statements

MiR-181b activates CYLD. 6 / 6
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"miR-21 and miR-181b act as an epigenetic switch to inhibit PTEN and CYLD tumor suppressors, leading to increased NF-kB activity required to maintain the transformed state XREF_BIBR."
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"Xu et al demonstrated that miR-181b regulated the proliferation of esophageal cancer stem like cells via the CYLD pathway and that CYLD was directly targeted by miR-181b."
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"Effects of miR-181b targeting CYLD on human colon cancer cell apoptosis and the NF-kappaB signaling pathway."
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"For example, PDCD4 is regulated by miR-21 and miR-183, and miR-181b can simultaneously target WIF-1 and CYLD."
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"Furthermore, the present study also demonstrated that miR-181b downregulation promoted CYLD upregulation and attenuated the activity of the NF-kappaB signaling pathway, thereby inhibiting cell growth and promoting cell apoptosis both in vitro and in vivo."
32901872
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"Downregulation of miR-181b inhibits human coloncancer cell proliferation by targeting CYLD and inhibiting the NF-kappaB signaling pathway."
32901872