IndraLab

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PSMD14 leads to the ubiquitination of E2F1. 3 / 3
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"For example, PSMD14 enhances tumor progression and chemoresistance in patients with head and neck squamous cell carcinoma by cleaving ubiquitinated E2F1, which activates the E2F1/Akt/SOX2 signaling pathway to promote stemness [31]."
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"Mechanically, PSMD14 inhibited the ubiquitination and degradation of E2F1 to improve the activation of Akt pathway and the transcription of SOX2."
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"Then, we pinpointed that PSMD14 inhibited ubiquitination and degradation of E2F1, which is consistent with the results reported previously XREF_BIBR."
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