IndraLab

Statements

Modified UCHL1 increases the amount of EGFR. 2 / 2
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"As expected, overexpression of UCHL1 (WT) significantly abrogated EGFR ubiquitination and increased EGFR levels, whereas this effect was reversed by UCHL1 (C90S; XREF_FIG)."
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"As expected, overexpression of UCHL1 significantly enhanced cardiomyocyte size, the mRNA level of ANF, and the protein levels of EGFR, and phosphorylated EGFR, AKT, and EKR1/2 compared with coinfection with Ad-GFP and siRNA-control after PE stimulation; moreover, this effect was markedly attenuated by coinfection with Ad-GFP or Ad-UCHL1 and siRNA-EGFR."
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