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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

Modified UCHL1 increases the amount of EGFR. 2 / 2

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"As expected, overexpression of UCHL1 (WT) significantly abrogated EGFR ubiquitination and increased EGFR levels, whereas this effect was reversed by UCHL1 (C90S; XREF_FIG)."

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"As expected, overexpression of UCHL1 significantly enhanced cardiomyocyte size, the mRNA level of ANF, and the protein levels of EGFR, and phosphorylated EGFR, AKT, and EKR1/2 compared with coinfection with Ad-GFP and siRNA-control after PE stimulation; moreover, this effect was markedly attenuated by coinfection with Ad-GFP or Ad-UCHL1 and siRNA-EGFR."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...